阿奇霉素对肺炎支原体肺炎的疗效及患儿体液免疫功能的影响  

Treatment Effect of Azithromycin on Mycoplasma Pneumoniae Pneumonia with Humoral Immuno-function Modulation in Pediatric Patients

作　　者：李锋[1] 王敬华[1] 张立红[1] 

机构地区：[1]河北省唐山职业技术学院临床系,063000

出　　处：《放射免疫学杂志》2008年第2期179-180,共2页Journal of Radioimmanology

摘　　要：目的：探讨阿奇霉素治疗肺炎支原体肺炎患儿的效果及其对患儿体液免疫功能的调节作用。方法：118例肺炎支原体肺炎患儿均常规退热、止咳、平喘和对症治疗，并随机分为实验组和对照组，前者采用阿奇霉素治疗，后者采用红霉素治疗。比较两组治疗有效率、副反应发生情况及两组患儿治疗前后血清IgM、IgG、IgA、补体C3和C4水平。结果：用药14d后，实验组和对照组的总有效率依次为96．55％和总有效为80％，副反应发生率依次为20．69％和60％，差异均有显著性（P〈0．01）。实验组治疗后的IgG、州、C3和C4水平均低于治疗前，差异有统计学意义（P〈0．01～0．05）。结论：阿奇霉素治疗肺炎支原体肺炎效果较好，并可以改善机体的体液免疫水平。Objective To study the treatment effect of azithromycin on pediatic patients with mycoplasma pneumoniae pneumonia. Methods Fiftyeight pediatric patients with mycoplasma pneumoniae pneumonia were treated with azithromycin. Another sixty patients were treated with erythromycin. The clinical results with changes of serum levels of IgM, IgG, IgA, C3 and C4 after treatment in the two groups were examined. ReSults The total effective rate in the azithromycin and erythromyein groups was 96.55% and 80% respectively, with adverse reaction rate of 20.69% and 60% respectively （both P 〈 0.01 ）. Serum IgG, IgM, C3, C4 contents dropped significantly in the azithromycin group after treamaent （P 〈 0.01 - 0.05 ）. Conclusion Treatment effect of azithromycin on pediatric patients with mycoplasma pneumoniae pneumonia was better than that of erythromyein with beffer modulation of humoral immuno function.

关 键 词：肺炎支原体 肺炎 阿奇霉素 体液免疫 

分 类 号：R725.631[医药卫生—儿科] R742.1[医药卫生—临床医学]