巨细胞动脉炎患者血管白介素6与信号传递子和转录激活子3的表达水平及其相关性  

Expressions and its relationship of vascular interleukin-6 and signal transducer and activator of transcription 3 in patients with giant cell arteritis

作　　者：谷绍娟[1] 胡治平[1] 

机构地区：[1]中南大学湘雅二医院神经内科

出　　处：《临床神经病学杂志》2008年第2期88-90,共3页Journal of Clinical Neurology

基　　金：国家自然科学基金资助项目(30470602)

摘　　要：目的研究巨细胞动脉炎(GCA)患者血管白介素-6(IL-6)与信号传递子和转录激活子3(STAT3)蛋白的表达水平及其相关性。方法用免疫组化方法,检测20例GCA和6例其他神经系统疾病患者(对照组)颞动脉中IL-6和STAT3蛋白的表达。同时记录GCA患者6项与炎症有关的指标,分为炎症指标≥3项组(7例)与≤2项组(13例)。并分析IL-6与STAT3蛋白表达水平的相关性。结果GCA组颞动脉IL-6阳性细胞评分、STAT3阳性细胞数分别为(2.85±0.75)分及(40.71±9.90)个/高倍视野,显著高于对照组[(2.00±0.63)分,(30.73±10.84)个/高倍视野](均P<0.05);GCA组炎症指标≥3项组IL-6、STAT3蛋白的表达水平显著高于炎症指标≤2项组(P<0.01,P<0.05);IL-6与STAT3蛋白表达水平呈正相关(r=0.883,P<0.05)。结论GCA患者血管IL-6、STAT3蛋白表达水平显著增高;两者表达水平呈正相关;提示IL-6可促进STAT3的表达。Objective To investigate the expressions and its relationship of vascular interleukin-6 （IL-6） and signal transducer and activator of transcription 3 （ STArI3 ） protein in giant cell arteritis patients. Methods The expressions of IL-6 and STArI3 protein were detected by immunohistochemistry in the temporal artery biopsy specimens of 20 patients with giant cell arteritis and 6 patients with other nerve system diseases （control group）. Six indexs related to inflammation in giant cell arteritis patients were recorded. Giant cell arteritis patients were divided into the group that≥3 positive indexs （7 cases） and the group that ≤2 positive indexs（ 13 cases）. The relationship between expressions of IL-6 and STArI3 protein was analysed. Results Compared with control group [ （ 2.00 ± 0. 63 ）score, （30.73 ± 10.84）cell/H], the expressions of IL-6 and STAT3 protein in temporal artery were significantly increased in giant cell arteritis group [ （2.85 ± 0.75 ） score, （40.71 ± 9.90） cell/H ] （ all P 〈 0. 05 ）. Moreover, the expressions of IL-6 and STArI3 protein in the patients who had ≥3 positive indexs were evidently increased than the ones who had ≤ 2 positive indexs （P 〈 0. 01, P 〈 0. 05 ）. There was a positive correlation between expressions of IL-6 and STArI3 protein（r =0. 883 ,P 〈0. 05）. Conclusions The expressions of IL-6 and STArI3 protein in the temporal artery of giant cell arteritis patients are prominently increased, and there is positive relationship between them, which suggests that IL-6 may upregulate the expression of STAT3.

关 键 词：巨细胞动脉炎 白介素-6 信号传递子和转录激活子3 血管平滑肌 

分 类 号：R543[医药卫生—心血管疾病]