房室结折返性心动过速与冠状窦及后延伸连接蛋白43表达的关系  

Relationship between atrioventricular nodal reentrant tachycardia and expression of connexin 43 in the coronary sinus and posterior extension

作　　者：郭维娜[1] 周聊生[2] 张明[2] 李琚平[2] 

机构地区：[1]山东大学医学院,硕士05级8班济南250012 [2]山东省千佛山医院保健科,济南250014

出　　处：《解剖学杂志》2008年第2期201-203,共3页Chinese Journal of Anatomy

基　　金：山东省科技攻关课题(2004GG02139)

摘　　要：目的:探讨房室结折返性心动过速(AVNRT)可能的发生机制。方法:通过电生理检查将新西兰大白兔分为双径路组与非双径路组,以冠状窦及后延伸(PNE)为研究标本,分别做H-E染色及连接蛋白43(Cx43)的免疫组织化学显色。结果:所有标本均可见右后延伸,3例标本可见左后延伸,后延伸Cx43阴性表达,双径路组冠状窦连接蛋白43表达强于左心房。结论:左后延伸构成了左房(二尖瓣环附近)至房室结的传导通路;左后延伸及右后延伸具有慢传导的一些特征;冠状窦可能参与了AVNRT的折返环。Objective： To study the possible mechanism of atrioventricular nodal reentrant tachycardia （AVNRT） from morphology and molecular biology. Methods： New Zealand rabbits were divided into two groups by electro-physiological examination： the dual-pathway group and non-dual-pathway group. Cx43 was observed by H-E and immunohistochemisty of the posterior extension and coronary sinus. Results： All specimens had the right posterior extension. Three specimens had the left posterior extension. The expression of Cx43 in posterior extension was negative. In the dual-pathway group, the expression of Cx43 in the coronary sinus was higher than that in the left atrium. Conclusion： The left posterior extension may contribute to the pathway from left atrium （near the annulus of mitral valve） to atrioventricular node; The left and right extension have characteristics of slow pathway; The coronary sinus may take part in the circulation of AVNART.

关 键 词：冠状静脉窦 连接蛋白43 房室结折返性心动过速 后延伸 

分 类 号：R541.7[医药卫生—心血管疾病]