弓形虫宫内感染动物实验与临床研究  

A Study on Intrauterine Infection by Tox. Gondii in Pregnant Women and Experimental Animals

作　　者：王海琦[1] 邵亚男[2] 张健宁[2] 冯振卿[2] 

机构地区：[1]南京医科大学第一附属医院妇产科 [2]南京医科大学基础同位素室

出　　处：《南京医科大学学报（自然科学版）》1997年第5期433-438,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金

摘　　要：应用放射核素１２５Ｉ－弓形虫感染孕１４天小白鼠，动态观察１２５Ｉ－弓形虫分布。结果证实，１２５Ｉ－弓形虫侵入孕鼠血液寄生于白细胞内，分布至脏器组织细胞胞浆内，少数在核内。孕鼠的单位重量组织的放射量由高到底顺序为肺、肝、脾、肾、心及脑，而胎鼠为头、肝、肺。胎鼠头／躯干放射量为１．３２∶５．９５。感染率胎盘为８５．８％，胎鼠为７６．８％（Ｐ＜０．０１）。临床跟踪５２例弓形虫感染孕妇，垂直传染胎儿２４例（４６．１５％），致不良妊娠结局１３例。提示临床对弓形虫感染孕妇应引起重视。Female mice at 14 days gestation were infected with 125 I Tox G. Then the distribution of 125 I Tox.G, at different time was observed. The results showed that the 125 I Tox.Gondii intruded into blood of pregnant mice and stayed in WBC. It was mainly distributed into cellulous plasma of internal organ tissue, few in nucleus. The sequence of radiodensity from high to low is lung, liver, spleen, kidney, heart and brain in pregnant mice; while head, liver, lungs in fetal mice. The radiodensity ratio of fetal mice head/body is 1.32～5.95, the infection rates of placenta and fetal mice are 85.5% and 76 8%( P <0.01) respectively. In 52 cases of pregnant women infected with Tox. Gondii, 24 had infected foetus (46.15%) and 13 resulted in poor pregnancy, suggesting that attention should be given to pregnant women infected with Tox.Gondii.

关 键 词：碘125 宫内感染 畸胎 弓形体感染 动物实验 

分 类 号：R711.320.2[医药卫生—妇产科学]