柴胡加龙骨牡蛎汤组方配伍研究(Ⅲ)——对慢性应激大鼠的抗抑郁作用  

Comparative study on the antidepressant-like effect of Chaihu-jia-Longgu-Muli-Decoction (CLMD) and its relative decoctions

作　　者：任鹏姣[1] 马世平[1] 瞿融[2] 谢娟[2] 陶方哲[2] 

机构地区：[1]中国药科大学中药药理教研室,南京210038 [2]南京中医药大学方剂教研室,南京210029

出　　处：《药学与临床研究》2008年第2期86-89,共4页Pharmaceutical and Clinical Research

基　　金：江苏省自然科学基金项目(BK2005149);江苏省中医药局中医药科研项目(H05074)

摘　　要：目的:比较柴胡加龙骨牡蛎汤与小柴胡汤的抗抑郁作用,探讨药物加减引起的药效改变,从而确定柴胡加龙骨牡蛎汤抗抑郁作用的主要组成药物。方法:采用不可预见性慢性的应激抑郁模型,观察小柴胡汤、柴胡加龙骨牡蛎汤以及后加入部分龙骨、牡蛎、桂枝、茯苓、大黄(龙牡桂苓军)对大鼠自发活动、糖水消耗、海马体积、肾上腺指数的影响。结果:经过21d慢性应激,大鼠出现开野实验水平得分及垂直得分均明显减少、糖水消耗量降低等抑郁状态,同时肾上腺指数较正常组显著升高,海马体积显著减小;经口给予柴胡加龙骨牡蛎汤及龙牡桂苓军部分可显著改善慢性应激抑郁模型大鼠的行为学和肾上腺、海马体积的变化。结论:小柴胡汤经过加减成为柴胡加龙骨牡蛎汤后,功效发生了明显的改变,这一结果提示柴胡加龙骨牡蛎汤的后加入部分(龙牡桂苓军)可能是该方抗抑郁的主要组成药物。Objective：To explore whether the added or deducted constructions can change the antide- pressant-like effect of Chaihu-jia-Longgu-Muli-Decoction （CLMD） comparating with Xiaochaihu-Decoction （XCD） , then to confirm the main composition of CLMD. Methods： The rat models were established by chronic unpredictable and intermediate stress stimulation, then the effects of CLMD, XCD and the added constructions on behavior, sucrose intake, hippocampal volime, adrenal index were ob- served. Results： Compared with control rats, the stressed rats showed obvious reduction in locomotor activaties and sucrose consumption, while the adrenal index increased and the hippocampal volume decreased. CLMD and the added constructions effectively improved the ethology and change of adrenal and hippocampal volime. Conclusion： When XCD had been added or reduced into CLMD, the indications were changed. Moreover, the added constructions maybe the major anti-depression component in CLMD.

关 键 词：柴胡加龙骨牡蛎汤 小柴胡汤 抗抑郁 

分 类 号：R285.5[医药卫生—中药学]