藏药镰形棘豆的镇痛抗炎活性  

Analgesic and anti-inflammatory activity of Tibetan medicine Oxytropis falcata

作　　者：王栋[1] 杨欢[1] 童丽[2] 蔡宝昌[1] 

机构地区：[1]江苏省中药炮制重点实验室 [2]青海大学医学院,西宁810001

出　　处：《药学与临床研究》2008年第2期90-93,共4页Pharmaceutical and Clinical Research

基　　金：教育部"春晖"计划(Z2006-1-81003);青海省科技厅项目(2007-N-534)

摘　　要：目的:对藏药镰形棘豆的镇痛和抗炎活性进行研究。方法:使用醋酸扭体法、热板法和福尔马林法确定镰形棘豆的镇痛效应和类型;使用二甲苯诱导的小鼠耳肿胀模型、卡拉胶诱导的小鼠腹腔炎模型和大鼠棉球肉芽肿模型探讨镰形棘豆的抗炎效应。结果:镰形棘豆总提取物经口服给药可明显减少由醋酸引起的小鼠扭体次数(57.2%);还可对抗由福尔马林诱发的第二相疼痛(40.1%);但是不能降低小鼠对热刺激的反应性。在抗炎试验中,镰形棘豆总提取物可显著地抑制模型小鼠的耳肿胀程度(58.0%)和白细胞的迁移(59.4%),以及模型大鼠肉芽组织的增生(49.2%)。结论:镰形棘豆具有良好的外周镇痛活性,对急性炎症和慢性炎症都有较好的作用。Objective：To investigate the analgesic and anti-inflammatory activity of Oxytropis falcata Bunge. Methods： The acetic acid-induced writhing test, hot plate test and formalin test were used to determine this effect and its analgesic type. The anti-inflammatory effect was determined by using the model of xylene-induced mouse ear edema, mouse carrageenan peritonitis and rat cotton pellets-induced granuloma, respectively. Results： Oral administration of extraction from Oxytropis falcata Bunge can significantly inhibit acetic acid-induced writhing in mice, maximum inhibition of writhing was observed at 1200 mg/kg dose （57.2%）. The extraction was remarkably active in the second phase of formalin-induced pain （ 1500 mg/kg dose, 40.1% ）, but not in the hot plate assay. In addition, the extraction could significantly produce anti-inflammatory effects, as demonstrated by maximum inhibition of mouse ear edema induced by xylene（58.0% ） , mouse peritonitis induced by carrageenan （59.4%）, and rat proliferation induced by cotton pellets （49.5%）. Conclusion： Oxytropis falcata Bunge may have peripheral but not central analgesic properties and have marked anti-inflammatory activity both on the acute phase and the chronic phase.

关 键 词：藏药 镰形棘豆 镇痛活性 抗炎活性 

分 类 号：R285.5[医药卫生—中药学]