依达拉奉治疗急性脑出血的临床疗效观察  

Clinical efficacy of edravone on the treatment of acute cerebral hemorrhage

作　　者：施俊峰[1] 李庆和[1] 王国祥[1] 

机构地区：[1]江苏省宜兴市人民医院神经内科,宜兴214200

出　　处：《药学与临床研究》2008年第2期134-136,共3页Pharmaceutical and Clinical Research

摘　　要：目的:观察依达拉奉对急性脑出血的临床有效性和疗程。方法:将136例急性脑出血患者随机分为3组:A组在脑出血常规治疗的基础上,组予依达拉奉30mg加和生理盐水100mL静脉滴注,每日2次,治疗14天;B组方案同A组,依达拉奉治疗7天,7天后同C组;C组按急性脑出血的常规治疗。3组分别在治疗前、治疗14天、治疗28天进行美国国立卫生研究院卒中患者神经功能缺损评分(NIHSS)和日常生活活动能力量表(BI)指数评定。结果:与治疗前比较,治疗组A和B在治疗后14天、28天的NIHSS显著降低及BI指数显著升高(P<0.05);与对照组C比较,治疗组A和B在14天和28天后NIHSS显著降低及BI评分显著升高(P<0.05);治疗组A与B之间无差异(P>0.05)。结论:依达拉奉治疗急性脑出血安全有效,疗程7天、14天疗效无区别。Objective： To investigate the effect of edaravone and its optimal regimem in the treatment of brain hemorrhage. Methods： 136 people suffered from brain hemorrhage were volunteerly divided into three groups randomly （ treatment group A ; treatment group B ; control group named group C ; ）. Group A was treated by routine therapeutic methods as well as giving 30 mg edaravone which was dissolved into 100mL saline through intravenous, twice a day for 14 days; Group B was similarly treated according to group A at the first 7 days but the following 7 days patients was cured according to group C; group C was treated by routine therapeutic methods, the total therapeutic time span of the above three groups is 14 days. Neural dysfunction of three group were evaluated by NISS and BI at pre-theray, 14 days and 28 days after therapy started respectively. Results： Compared with time point of pretherapy, NISS and BI index of group A and group B were significantly lower at time point 14 days and 28 days （P 〈 0. 05 ） ; NISS and BI index of group A and group B were significantly lower than group C at time point 14 days and 28 days （ P 〈 0. 05 ） ; But no significant difference was found between group A and group B （P 〉0.05 ）. Conclusion： Edaravone can cure brain hemorrhage safely and effectively, there was no difference between two courses of treatment of 7-days and 14-days.

关 键 词：急性脑出血 依达拉奉 疗效 

分 类 号：R969.4[医药卫生—药理学]