HIV阳性的海洛因依赖者戒毒前后120天CD4^+T变化  

An analysis of difference of CD4^+ T cells of heroin addicts with HIV-positive before and after detoxitication

作　　者：徐靖[1] 张勇[2] 石向东[3] 冯铁建[3] 周海涛[2] 

机构地区：[1]深圳市公安局强制戒毒所,广东深圳518019 [2]深圳市福田区疾病预防控制中心,广东深圳518040 [3]深圳市疾病预防控制中心,广东深圳518020

出　　处：《中国药物滥用防治杂志》2008年第2期91-93,共3页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：广东省自然科学基金项目(06301434)

摘　　要：目的:分析HIV阳性的海洛因依赖者戒毒前后(120天)CD4+T细胞的变化趋势,探讨戒毒对免疫功能的影响。方法:共有HIV阳性海洛因依赖者19例和同期HIV阴性海洛因依赖者25例入选本项研究。在入所7天内及戒毒120天后两次采集外周血,经流式细胞仪进行CD4+T细胞检测计数,SPSS11.5软件包统计分析。结果:HIV阳性与阴性者CD4+T细胞计数均值差异显著,HIV阳性的海洛因依赖者入所时CD4+T细胞计数值多数低于450×106/L,也有部分高于450×106/L。HIV阴性的海洛因依赖者CD4+T细胞计数均值戒毒后轻微下降。HIV阳性者CD4+T细胞计数均值戒毒后轻微上升,但两组间戒毒前后差值无统计学意义,组内CD4+T细胞计数戒毒前后无统计学差异。HIV阳性,且入所时CD4+T细胞值低于450×106/L的海洛因依赖者,戒毒120天后CD4+T细胞计数值显著上升,戒毒前后计数配对t检验,P﹤0.01,差异高度显著。结论:海洛因依赖合并HIV感染且已表现免疫功能受损者戒毒有助于其CD4+T细胞回升,从而延缓艾滋病发病。Objective： To analyze the trend of CD4^＋ T cells of heroin addicts with HIV-positive before and after detoxification （120 days）, and to assay drug effects on immune function. Methods： A total of 19 cases of HIV-positive heroin abusers and 25 cases HIV-negative heroin abusers were selected in study. Fasting peripheral venous blood 2 mL was collected at the beginning of detoxification and 120 d of detoxifying. CD4^＋ T cell werecounted detected by flow cytometry. Statistical difference was analysis by SPSS software package between the two groups and before and after detoxification. Results： There were significant differences of CD4Aa^＋ T cell count between HIV-positive heroin addicts and HIV-negative heroin abusers before and after treatment. Majority count of HIV-positive less than 450 × 10^6/L, but a small part of HIV-positive addicts highter than 450 × 10^6/L. The mean of CD4^＋ T cell count of HIV negative heroin abusers decreased slight, and the mean count of HIV positive increased slight after detoxification for 120 days, but the algebraic difference of the CD4^＋ T-cell count from the beginning to the 120 d of detoxifying between the two groups was no statistical significance. The CD4^＋ T cell count at the beginning and 120 d of detoxifying were no significant differences also for each group. But in the HIV-positive group, for the part of CD4^＋ T cell count less than 450 × 10^6/L at beginning, the count increased significantly （P〈0. 001）. Conclusions： Detoxifying is helpful for the heroin addicts combination with HIV infection and displayed immune function damage detoxifying to recovery the count ofCD4^＋ T cell, and delayed the aids onset.

关 键 词：海洛因依赖者 戒毒 HIV感染 CD4^+T细胞 

分 类 号：R512.91[医药卫生—内科学] R749.64[医药卫生—临床医学]