慢性房颤华法令抗凝治疗的理想INR值探讨  

Study of the optimal range of international normalized ratio(INR) for patients with chronic atrial fibrillation receiving warfarin for anticoagulation

作　　者：徐中林[1] 赵义发[1] 吴兰兰[1] 

机构地区：[1]重庆第九人民医院心内科,重庆400700

出　　处：《现代医药卫生》2008年第9期1281-1282,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨慢性房颤华法令抗凝治疗的理想国际标准化比值(INR)。方法:对115例有血栓栓塞高危因素的慢性房颤患者给予华法令抗凝治疗,定期随访INR,同时观察治疗中发生的血栓栓塞和出血事件。结果:115例患者中有8例共10次发生血栓栓塞事件,7例7次发生与抗凝有关的出血事件,10次血栓栓塞事件中9次发生在INR<1.7,而所有的出血事件都发生在INR>3.5,INR 1.7～3.5时栓塞或出血发生率均较低。结论:INR 1.7～3.5是慢性房颤华法令抗凝治疗较理想的抗凝强度。Objective：To study the optimal range of international normalized ratio （INR） for patients with chronic atrial fibrillation receiving warfarin for anticoagulation. Methods： 115 patients with chronic atrial fibrillation all received warfarin for anticoagulation.The INR was regularly followed up and the events of thromboembolism and the INR-specific of haemorrhagia were calculated.Results：Eight of the 115 patients experienced 10 thromboembolic events and seven patients experienced 7 haemorrhagic events.Nine of 10 thromboembolic events occurred at INR〈1.7 and all haemorrhagic events occurred at INR〉3.5.The incidence rate of either haemorrhagic or thromboembolic events was lowest at INR between 1.7 and 3.5. Conclusion：INR of 1.7-3.5 appeared to be the optimal range of INR associated with the lowest incidence rate of major haemorrhagic or thromboembolic events for patients with chronic atrial fibrillation receiving warfarin for anticoagulation.

关 键 词：心房颤动 抗凝 栓塞 

分 类 号：R5[医药卫生—内科学]