市售品补钙制剂的补钙效果观察  

EFFECT OF COMMERCIAL FORTIFIED CALCIUM PRODUCTS ON CALCIUM STATUS IN RATS

作　　者：荫士安[1] 徐青梅[1] 胡善明[1] 赵显峰[1] 孟晶[1] 葛可佑[1] 

机构地区：[1]中国预防医学科学院营养与食品卫生研究所

出　　处：《营养学报》1997年第3期333-339,共7页Acta Nutrimenta Sinica

基　　金：中美合资苏州立达制药有限公司的部分经费

摘　　要：以大鼠为模型，研究市售数种钙剂的补钙效果。选用三周龄断乳Ｗｉｓ－ｔａｒ大鼠１０８只，雌雄各半，喂饲３周缺钙饲料后，按体重随机把大鼠分成９组，即以基础饲料为缺钙对照组，以碳酸钙为补钙正对照组，其它７组为市售商品钙制剂，包括：１．碳酸钙＋ＶＤ产品、２．中药补钙＋ＶＤ产品、３．骨粉产品、４．活性钙片、５．活性钙冲剂、６．乳酸钙冲剂、７．醋酸钙产品。按产品标识量加入３０００ｍｇ钙／ｋｇ，使饲料含钙量达到大鼠推荐量的８０％。补钙各组大鼠终体重和身长均非常显著高于对照组。补充商品钙制剂组的血浆、红细胞和肝脏中钙含量均显著高于缺钙对照组，补钙各组间无显著差异。多数钙制剂对雄性肾脏钙存留的影响不显著，只有活性钙片和中药补钙＋ＶＤ显著增加雄性大鼠肾脏钙存留；补钙对雌性大鼠肾脏钙存留的影响非常显著。补充商品钙剂均显著增加骨矿物质含量，醋酸钙冲剂和活性钙的效果似不如其它钙制剂。按效果价格比，目前碳酸钙仍是最好的钙源。Rat was used as animal model for evaluating the effects of different chemical forms of calcium(Ca) and commercial fortified Ca products on improving Ca status.One hundred and eight three weeks weaning Wistar rats were selected,half male and female. After three weeks feeding with Ca deficient diet,the rats were randomly divided into nine groups by body weight,consuming a Ca deficient diet,or diets supplemented with Ca carbonate,caltrate D(Ca carbonate+vitamn D),Chinese herbs fortified with vitamin D,active Ca tablets,bone meals,active Ca beverage,lactate Ca beverage,and acetate Ca beverage respectively at the level of 3 000mg Ca per kg feed for 12 weeks. The results showed that the final body weight and length in all groups supplemented with Ca were significantly higher than that of the deficient group.Ca concentrations in plasma,erythrocytes and liver of rats supplemented with Ca were significantly higher than that of control group,whereas there were no significantly differences among all the supplemented groups.Most of commercial fortified Ca products could not markedly increase Ca retention in kidneys of male rats except active Ca tablets.The addition of Ca had very significant effect on increasing Ca retention in kidney of female rats.The supplementation of Ca can significantly increase bone mineral content in rat femur. Among the commercial fortified Ca products acetate Ca beverage and active Ca products are not so as the other commercial fortified Ca products for increasing bone mineral content. Based on the ratio of efficiency to price, Ca carbonate is still a good source for increasing Ca intake at present.

关 键 词：碳酸钙 钙制剂 补钙 

分 类 号：R977.5[医药卫生—药品]