产超广谱β-内酰胺酶铜绿假单胞杆菌医院获得性肺炎临床分析  

Analysis of risk factors for nosocomial pneumonia due to ESBLs producing Pseudomonas aeruginosa

作　　者：邴宇红[1] 邵宏伟[1] 仇威[1] 

机构地区：[1]中国医科大学第八临床学院鞍钢总医院,辽宁鞍山114002

出　　处：《现代医药卫生》2008年第10期1444-1445,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨产超广谱β-内酰胺酶(ESBLs)铜绿假单胞杆菌医院获得性肺炎的临床危险因素。方法:选取2003年7月～2005年7月鞍钢总医院收治的铜绿假单胞杆菌医院获得性肺炎101例,38例产ESBLs铜绿假单胞杆菌医院获得性肺炎作为观察组,63例非产ESBLs铜绿假单胞杆菌医院获得性肺炎作为对照组。对产ESBLs肺炎铜绿假单胞杆菌病例的危险因素进行对照研究。结果:ES-BLs阳性组对12种抗生素的耐药性远远高于ESBLs阴性组。单因素分析发现住院时间大于20天、入住重症监护病房(1CU)、气管插管或切开、留置导管、机械通气、头孢噻肟的使用是产ESBLs肺炎铜绿假单胞杆菌引起医院获得性肺炎的主要危险因素。多因素非条件logistic回归分析表明,头孢噻肟的使用是产ESBLs肺炎医院获得铜绿假单胞杆菌性肺炎的独立危险因素。结论:住院时间长、入住ICU等是ESBLs铜绿假单胞杆菌医院获得性肺炎发生的危险因素,尤以头孢噻肟的使用是主要危险因素。Objective：To analyze the risk factors of nosocomial pneumonia due to ESBLs producing Pseudomonas aeruginosa. Methods：From July 2001 to December 2004, 38 patients with ESBL producing P. aeruginosa and 63 patients with non- ESBLs produeing P.aeruginoaa were enrolled. ESBLs producing strains were detected by confirmed test.Results：Hospital duration, ICU stay ,tracheal intubation or traeheotomy ,indwelling catheters ,mechanical ventilation and use of cefotaxime were found to be risk factors in the acquisition of P.aeruginosa with ESBLs by univariate analysis. Cefotaxlme use remmned as risk factors by multivariate analysis with logistic regression. Conclusion：The reasonable use of cefotaxime is an important measure to control the prevalence of ESBLs producing strains of Pseudomonas aeruginosa.

关 键 词：铜绿假单胞杆菌 超广谱Β-内酰胺酶 危险因素 

分 类 号：R5[医药卫生—内科学]