拉米夫定联合安珐特治疗慢性乙型病毒性肝炎肝纤维化的临床研究  

Clinical research on the treatment of hepatic fibrosis in chronic hepatitis B by combined use of lamivudine and An-Fa-Te

作　　者：何吕富 

机构地区：[1]903医院

出　　处：《现代医药卫生》2008年第10期1447-1448,共2页Journal of Modern Medicine & Health

摘　　要：目的:研究拉米夫定与复方牛胎肝提取物(商品名安珐特)联合治疗慢性乙型病毒性肝炎肝纤维化的临床疗效。方法:62例慢性乙型肝炎肝纤维化患者随机分为两组:对照组30例给予甘草酸二铵、还原型谷光甘肽、维生素C等保肝治疗。治疗组32例在对照组治疗的基础上口服拉米夫定100mg/天,安珐特2片/次,3次/天。疗程均为6个月。治疗前后检测患者血清透明质酸(HA)、层黏蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(ⅣC)水平,观察肝功能指标及乙肝病毒指标。结果:治疗组肝功能、乙肝病毒指标及血清肝纤维化指标有明显改善,与治疗前比较或与对照组比较差异均有显著性(均P<0.01)。结论:拉米夫定与安珐特联合应用,不但能有效改善肝功能、抑制病毒复制,而且有很好的抗肝纤维化作用。Objective：To study the clinical effect of lamivudine associated with compound fetal bovine liver extract tablets,ie An- Fa-Te （AFT） in treating hepatic fibrosis in chronic hepatitis B （CHB）.Methods：Sixty-two patients with CHB were randomly divided into two groups：control group was treated with diammonium glycyrrhizinate,glutathione,vitamin C etc,at the same time,the patients in the treatment group took the same general medicine and were added with lamivudine 100 mg per time and 1 times per day and AFT 2 tablets per time and 3 times per day,both two groups had 6 months treating time.Before and after treatment,the marks of hepatic fibrosis such as hyaluronia acid （HA）,laminin （LN）,procoUagen typeⅢ （PCⅢ） and procollagen typeⅣ （Ⅳ-C） were detected in all the patients,and liver function（Tbil, ALT, AST, Alb）, HBVDNA and HBV-M were also observed. Results： The marks of hepatic fibrosis,liver function, HBVDNA and HBV-M in the treatment group were significantly improved compared with those before treatment, with significant difference between them（P〈0.01）. Conclusion：Lamivudine associated with AFT has a significant effect to improve liver function, HBVDNA and HBV-M, and can correct the mark of hepatic fibrosis.

关 键 词：乙型肝炎 慢性 肝纤维化 拉米夫定 治疗 安珐特 

分 类 号：R5[医药卫生—内科学]