金属硫蛋白抗镉性肾毒作用的试验研究  

Experimental study on the preventive effect of metallothionein(MT) in cadmium nephrotoxicity

作　　者：杜理国[1] 王翔朴[1] 安飞云[1] 高泽宣[1] 王安[1] 王夷平[1] 

机构地区：[1]湖南医科大学环境医学研究室

出　　处：《职业医学》1997年第5期4-6,共3页China Occupational Medicine

基　　金：国家自然科学基金

摘　　要：采用亚急性镉中毒性肾损害动物模型，观察了金属硫蛋白（ＭＴ）对镉性肾损害的保护作用。结果显示：在镉致肾损害的过程中，可见ＭＤＡ含量增加、ＳＯＤ活性降低，表明镉具有诱导肾脏的脂质过氧化作用。用硫酸锌事先诱导ＭＴ的合成，可延缓镉性肾损害出现的时间和减轻肾损害的程度，表明ＭＴ具有抗镉性肾损害的作用。Using subacute cadmium induced nephropathic animal model,the protective effect of MT against cadmium induced renal damages was observed The result showed that the content of malondialdehyde(MDA) increased and the activity of superoxide dismutase(SOD) decreased during cadmium renal damage,indicating that cadmium might cause lipid peroxidation in the kidney It would delay the onset and weaken the degree of renal damages if ZnSO 4 was administered beforehand as to promote the syntheses of MT It suggested that MT could protect the kidney from cadmium damages

关 键 词：肾损害 金属硫蛋白 镉中毒 

分 类 号：R595.202[医药卫生—内科学] R692.05[医药卫生—临床医学]