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机构地区:[1]山东大学齐鲁医院中西医结合妇科,山东济南250012
出 处:《上海中医药杂志》2008年第4期41-43,共3页Shanghai Journal of Traditional Chinese Medicine
基 金:山东省中医药管理局基金资助项目(2003-114)
摘 要:目的观察益肾活血汤治疗排卵功能障碍性不孕症的临床疗效并探讨其作用机制。方法将90例患者随机分为益肾活血汤治疗组60例和克罗米酚对照组30例,观察治疗前后两组患者性激素水平、子宫内膜厚度、排卵率及妊娠率。结果治疗组与对照组总排卵率无明显差异;治疗组妊娠率明显优于对照组(P<0.05);治疗组血清E2、LH、FSH含量较对照组升高(P<0.05,P<0.01),PRL则明显下降(P<0.01);治疗后治疗组子宫内膜厚度的改善程度优于对照组(P<0.05,P<0.01)。结论益肾活血汤能促进卵泡及子宫内膜生长发育,改善卵巢的分泌功能,从而达到助孕的目的。Objective To observe the clinical effects of "Yishenhuoxue Decoction" (YSHD) in treating infertility due to ovulatory dysfunction and to explore its mechanism. Methods Ninety subjects were randomly divided into treatment group with 60 cases and control group with 30 cases. Treatment group was treated with YSHD, and control group with clomiphene citrate (CC). The changes of the growth of endometrium and the follicle, the status of ovulating, follicle-stimulating hormone (FSH). luteinizing hormone (LH). prolactin (PRL), estradiol(E2), progesterone(P) and testostetrone(T) were observed. Results The two groups had similar ovulating rate, but the pregnancy rate in treatment group was superior to that in control group (P〈0.05). The contents of E2, LH and FSH were higher in treatment group than in control group (P〈0.05,P〈0.01), but the content of PRL was lower (P〈0.01). and there was an obvious difference in the thickness of endometrium (P〈0.05,P〈0.01). Conclusion YSHD can promote the growth of the follicle, and also thicken endometrium and adjust ovary function, which are beneficial to pregnancy.
关 键 词:不孕症 排卵障碍 益肾活血汤 妊娠率 排卵率 性激素 子宫内膜
分 类 号:R271.14[医药卫生—中医妇科学]
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