扶正固本法对特应质青少年基因表达的影响  

Adjusting Effects of Health-Supporting Therapy on Gene Expressions of Hobbledehoy Atopy

作　　者：贯剑[1] 郑湘瑞[2] 周飞 何裕民[4] 侯风刚[5] 

机构地区：[1]上海市第八人民医院,上海200235 [2]河南中医学院基础医学院,河南郑州450008 [3]上海市针灸经络研究中心,上海201203 [4]上海中医药大学基础医学院,上海201203 [5]上海市中医医院,上海200071

出　　处：《上海中医药杂志》2008年第4期49-51,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30100234)

摘　　要：目的探讨中药在基因水平调整过敏体质的机制。方法选择花粉症、哮喘、特应性皮炎患者为研究对象,应用扶正固本中药进行治疗,疗程为6个月;观察治疗前后IgE高亲和力受体β链基因(FcεRIβ)、白介素5受体α链基因(IL-5Rα)、人类白细胞抗原(HLA-A)表达以及临床症状、免疫球蛋白E(IgE)等的变化情况。结果各治疗组治疗前后基因表达均有改变,临床症状、IgE亦有改善。结论提示中药可以改变体内高致敏状态,缓解青少年过敏症状。Objective To evaluate the adjusting effects of herbs on atopy. Methods The trial involved patients with hay fever, atopic dermatitis and asthma, who were treated by health-supporting therapy for six months; the clinical symptoms,IgE and FcεRIβ, ILT-5Rα and HLA-A in blood were observed. Results The clinical symptoms, IgE and above genes were significantly improved after treatment. Conclusion The herbs are effective in adjusting atopy.

关 键 词：特应质 中医药疗法 基因 

分 类 号：R242[医药卫生—中医临床基础]