志贺菌耐药性的分子机制  

The Molecular Mechanisms of Drug Resistance in Shigella

作　　者：魏小娟[1] 张继瑜[1] 李剑勇[1] 周绪正[1] 牛建荣[1] 李金善[1] 王松泰[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,甘肃兰州730050

出　　处：《畜牧兽医杂志》2008年第3期34-35,共2页Journal of Animal Science and Veterinary Medicine

基　　金：国家自然科学基金资助项目(编号:30671582)

摘　　要：随着抗菌药物的广泛应用,耐药及多重耐药细菌已经严重威胁着人类和动物的健康。志贺菌的耐药机制主要是产生灭活酶、细胞壁的改变、主动外排以及作用靶位结构的改变。本文对其耐药机制的研究进展作简要综述。The irrational application of antibiotics has seriously threatened the health of human being because of the continuously increasing drug--resistant of bacteria. The drug--resistance mechaniam of shigella caused by producing inactived enzyme, changing cell walls, target site structure and active efflux pump. The paper summarizes the research progress of drug--resistance mechaniam in shigella.

关 键 词：志贺菌 耐药性 分子机制 

分 类 号：S855.1[农业科学—临床兽医学]