喷他脒的电化学行为及其应用  

Electrochemical Behavior of Pentamidine and Its Application

作　　者：杨冉[1] 杨素玲[1] 屈凌波[1] 李建军[1] 

机构地区：[1]郑州大学化学系,郑州450052

出　　处：《理化检验（化学分册）》2008年第4期304-306,318,共4页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：国家自然科学基金资助项目(20472076);河南省杰出青年科学基金资助项目(0512001400)

摘　　要：采用循环伏安法研究了喷他脒在玻碳电极上的电化学行为,应用微分脉冲伏安法提出了喷他脒不需分离的直接测定方法。在0.1 mol·L^-1（pH 8.5）磷酸二氢钠-磷酸氢二钠溶液中,喷他脒于电位-1.56 V（vs.SCE）有一灵敏的还原波;试验证明该波是喷他脒的催化氢波,还原波峰电流与喷他脒浓度在2.0×10^-5-8.0×10^-4mol·L^-1范围内呈线性关系,相关系数为0.997 3,检出限为1.6×10^-5mol·L^-1;采用标准加入法测定尿液中样品,回收率在95.1%-103.8%之间。Electrochemical behavior of pentamidine （PTM） was studied by cyclic vohammetry., As shown by experimental results, in a phosphate buffer of pH 8.5, a sensitive reduction wave produced by PTM was observed at the potential -1.56 V （vs. SCE）, which is proved to be a catalytic hydrogen wave. Linear relationship was held between peak current of the reduction wave and concentration of PTM in the range of 2. 0× 10^-5 -8.0× 10^-4mol · L^-1（r=0. 997 3）. Detection limit of the method was found to be 1.6× 10^-5mol · L^-1. Based on these facts, a derivative pulse vohammetric method of direct determination of PTM without necessity of separation was proposed. Recovery test was performed by addition of standard PTM solution to a urine sample, and the results obtained were in the range of 95. 1%-103. 8%.

关 键 词：微分脉冲伏安法 喷他脒 电化学行为 催化氢波 

分 类 号：O657.1[理学—分析化学]