吲哚美辛治疗兔SMAO休克的作用机制及给药时机  

Action mechanism and time of administration of indomethacin in SMAO shock rabbits

作　　者：魏辉明[1] 张丽翎[2] 

机构地区：[1]成都军区昆明总医院麻醉科 [2]昆明医学院中心实验室

出　　处：《中华麻醉学杂志》1997年第10期606-606,共1页Chinese Journal of Anesthesiology

摘　　要：目的：研究吲哚美辛对ＳＭＡＯ休克兔作用机制及给药时机。方法：３２只ＳＭＡＯ休克兔随机均分四组：对照级（Ａ）、夹闭时给药组（Ｂ）、松夹时给药组（Ｃ）和松夹３０分给药组（Ｄ），给药组均静注吲哚美辛５ｃｍ／ｋｇ，观察休克４小时内存活情况、血动学、血钙、心肌组织钙和ＴＸＢ２与６ｋｅｔｏ－ＰＧＦ１α含量，并作镜观察。结果：用药组存活率高于对照组，血流动力学改善，血钙稳定，Ｂ、Ｃ两组心肌钙含量降低。To study action mechanism and time of administration of indomethacin in SMAO shock rabbits. Method:Thirty-two SMAO shock rabbits were randomly divided into four groups: control group A,indomethacin 5mg/kg I.V. at the occlusion of superior mesenteric artery (group B), indomethacin 5mg/kg L V. immediately after clamp being removed(group C) and the same dose 30min after clamp being removed(group D). Survival rate,hemodynamics, plasma calcium, myocardial calcium, TXB_2 and 6-keto-PGF_1. levels were observed in 4h shock period. Myocardial apecmen were examined with electronic microscope. Result: After indomethacin I.V,the survival rate was higher and bemodynamie better than those of controll. The plasma calcium level remained stable in indomethacin groups. Myocardial calcium content of group B and C was lower than that of group D and A. The TXB_2 and 6-ketoPGF_1. contents were similar in all groups. Under electronic microscope, the damages were slightest in group C and most serious in group D and A among the four groups. Conclusion:Indomethacin has a beneficial effect on the SMAO shock rabbits ,the mechanism of which can be related to improving myocardium contractivity as well as to blocking calcium channel,rather than the action through prostaglandins. The time of administration should be early as possible after shock.

关 键 词：吲哚美辛 血液动力学 SMAO 休克 

分 类 号：R441.9[医药卫生—诊断学] R614[医药卫生—临床医学]