乙型肝炎病毒前S1抗原、HBV-DNA含量与HBeAg的相关性分析  

Analysing the relativity of HBeAg、HBV pre-S1 antigen and HBV-DNA content

作　　者：严伟玲 张志强[2] 

机构地区：[1]广东省惠州市小金口医院,广东惠州516023 [2]广东省惠州市中心人民医院,广东惠州516001

出　　处：《海南医学》2008年第5期3-4,共2页Hainan Medical Journal

摘　　要：目的分析乙型肝炎病毒前S1抗原、HBV-DNA含量与HBeAg在反映乙肝病毒复制方面的相关性。方法收集HBsAg阳性的血清标本524例,使用ELISA法检测HBV-M(包括HBsAg、HBsAb、HBeAg、HBeAb、HBcAb及前S1抗原)。采用核酸扩增荧光定量(FQ-PCR)检测HBV-DNA。结果HBeAg、前S1抗原及HBV-DNA的阳性率依次是30.5%、54.6%、75.2%,HBeAg阳性率最低,HBV-DNA阳性率最高。结论在反应病毒复制水平上,乙型肝炎病毒前S1抗原、HBeAg与HBV-DNA有一定的相关性,但其检出率并不一致,临床应正确认识三者的检测价值及临床意义,合理选择检测项目。Objective To analyse the relativity of HBeAg、HBV pre-S1 antigen and HBV-DNA content, which reflect the state of HBV infection and replication. Methods The content of HBV-DNA was detected by fluorescence quantitative PCR （FQ-PCR） when HBV-M was detected by ELISA in 524 serum samples whose HBsAg is positive. Results The positive rates of HBeAg、pre-S1 antigen and the content of HBV-DNA are 30.5%、54.6%、75.2% in turn, of which HBeAg is the lowest and the content of HBV-DNA is the highest. Conclusion Although HBeAg、HBV pre-S1 antigen and the content of HBV-DNA have some relativity with each other when they reflect the state of HBV infection and replication, their positive rates are different. We should know their importance and clinic signification to choose the valuable item.

关 键 词：乙型肝炎病毒 前S1抗原 HBV—DNA HBEAG 相关性 

分 类 号：R512.62[医药卫生—内科学]