右旋布洛芬缓释栓的制备工艺及其体外释放特性研究  

Preparation and Release of Dexibuprofen Suppositories in vitro

作　　者：谢斌[1] 丁玉峰[1] 贺国芳[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《医药导报》2008年第5期522-525,共4页Herald of Medicine

摘　　要：目的制备右旋布洛芬缓释栓,评价其体外释放特性。方法用正交实验设计,对右旋布洛芬缓释栓的处方和工艺进行筛选与优化,用筛选的最佳处方制备右旋布洛芬缓释栓,测定其体外释放特性。结果以优选的处方和工艺制备的栓剂,体外释药性能良好,符合Higuchi模型,体外释药能持续>8h。结论该处方设计合理,制剂制备工艺可行,质量控制方法可靠。Objective To prepare dexibuprofen sustained release suppositories and evaluate its drug release characteristics in vitro. Methods The optimal formulation and preparation technology of the suppositories were found with orthogonal design, which was used to prepare and detect the release of suppositories in vitro as well. Results The released rate of the prepared suppositories was consistent with the Higuchi equation and drugs could be sustained released in vitro over 8 hours. Conclusion The formulation is reasonablly designed, and the preparation technology is feasible to carry out and the method of quality control is reliable to use.

关 键 词：右旋布洛芬 缓释栓 正交设计 制备工艺 累积释放度 质量标准 色谱法 高效液相 

分 类 号：R971.1[医药卫生—药品] R94[医药卫生—药学]