参桂前列爽胶囊抗实验性前列腺增生的研究  

Effects of ShenGuiQianLieShuang Capsule against Experimental Prostate Hyperplasia

作　　者：徐平湘[1] 成亮[1] 高建[1] 陈怡[1] 唐玉[1] 郜文[2] 白江洪[3] 

机构地区：[1]首都医科大学基础医学院药理教研室 [2]首都医科大学药物研究所 [3]首都医科大学附属北京友谊医院中药房

出　　处：《首都医科大学学报》2008年第2期171-174,共4页Journal of Capital Medical University

基　　金：北京市属市管高等学校人才强教计划资助项目-拔尖创新人才资助项目~~

摘　　要：目的观察参桂前列爽胶囊对实验性前列腺增生动物模型的作用。方法本实验采用去势后皮下注射丙酸睾丸酮(0.5mg/每只鼠)的方法制作大鼠前列腺增生的模型,每日一次灌胃给予不同剂量的参桂前列爽胶囊,以普乐安片作为阳性药对照,4周后观察大鼠前列腺腺体的干、湿质量,并在光镜下观察腺体的病理学改变。同时采用16d胎龄小鼠尿生殖窦组织埋入前列腺诱发小鼠前列腺增生的模型,检测给药4周小鼠前列腺的质量和腺体组织中酸性磷酸酶含量的变化。结果与模型组相比,参桂前列爽胶囊大、中剂量组(10.8g/kg、5.4g/kg)和普乐安片组(2.5g/kg)大鼠前列腺干湿质量及湿质量指数明显降低;小剂量组(2.7g/kg)前列腺湿质量及湿质量指数明显降低;干质量及干质量指数有所下降,但差异无统计学意义;病理学检测显示,参桂前列爽胶囊大、中剂量组的前列腺组织增生明显减轻,腺上皮高度明显减少。同样,在尿生殖窦植入引起的小鼠前列腺增生模型中,参桂前列爽胶囊大、中剂量组(15.0g/kg、7.5g/kg)和普乐安片组(3.5g/kg)可以降低前列腺腺体湿质量及湿质量指数,明显降低小鼠腺体组织中酸性磷酸酶含量。结论上述实验结果表明参桂前列爽胶囊具有明显抑制前列腺增生的作用,其机制可能与抑制前列腺中酸性磷酸酶有关。Objective To observe the effects of ShenGuiQianLieShuang capsule （QLS） against experimental benign prostatic hyperplasia（BPH） in rats and mice. Methods The experimental BPH model was induced in castrated rat with subcutaneous injection of testosterone propionate once daily for four weeks at a dosage of 0.5 mg/rat, at the same time different doses of QLS and Pule, an tablet were administrated orally in the same way. At the end of experiment, the weight of prostate was measured and the pathological changes in prostate were observed under light microscope. Another experimental BPH model was induced in male mice by implanting of fetal urogenital sinus（from 16 d fetal mice） into the prostate tissue, QLS capsule and Pule were given for four weeks after the implanting. At the end of experiment, the weight of prostate and the content of prostatic acid phosphatases（PAP） in prostate were measured. Results Compared with the model group, the wet（ and dry） weight and the weight index of prostate were decreased significantly in both QLS groups （10.8 g/kg, 5.4 g/kg） and Pule, an group（2.5 g/kg） in the rat BPH model（P 〈0.01）. The wet（and dry） weight and the weight index of prostate were also decreased in QLS group at the dosage of 2. 7 g/kg, though there was no statistically difference. The pathological changes of prostate were ameliorated in QLS groups（ 10.8 g/kg, 5.4 g/kg） and Pule, an group（2.5 g/kg） , including the height of epithelial cells and the hyperplasia of prostate gland. In the mice BPH model, significant decreasing effects were found in PAP level, wet weight and the weight index of prostate in QLS groups（ 15.0 g/kg, 7.5 g/kg） and Pule, an group（3.5 g/kg）. Conclusion ShenGuiQianLieShuang capsule shows a protective effect against experimental benign prostatic hyperplasia, and the inhibition of PAP in prostate may be involved in the mechanism.

关 键 词：参桂前列爽胶囊 前列腺增生 酸性磷酸酶 

分 类 号：R697.32[医药卫生—泌尿科学]