ET-1神经分布异常与高血压鼠脑动脉神经源性调节的关系  

RELATIONSHIP BETWEEN ABNORMAL ENDOTHELIN-1 INNERVATION AND NEUROGENIC REGULATION OF CEREBRAL ARTERIES IN HYPERTENSIVE RATS

作　　者：林雪群[1] 祝高春[1] 万丽丹[1] 

机构地区：[1]南昌大学医学院脑血管研究所解剖学教研室,南昌330006

出　　处：《中国组织化学与细胞化学杂志》2008年第1期61-64,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：卫生部科学基金资助(98-1-337);江西省自然科学基金(0440062);南昌大学博士科研基金

摘　　要：目的探讨ET-1(Endothelin-1,ET-1)能神经纤维分布与高血压鼠脑血管的神经源性调节的关系,探讨ET-1神经是否参与高血压时期脑血流的调节。方法应用免疫组织化学技术观察自发性高血压鼠和Wistar正常血压鼠脑底动脉(包括大脑前动脉、大脑中动脉、大脑后动脉和基底动脉)ET-1能神经纤维的分布密度和走行方式。结果自发性高血压鼠和Wistar正常血压鼠脑底动脉均可见棕褐色的ET-1能免疫反应阳性纤维,似细线状,攀附于血管壁上,自发性高血压鼠脑底动脉各主要分支ET-1能免疫反应阳性纤维密度较Wistar正常血压鼠明显增加,纤维走行大多呈网状。结论实验结果提示自发性高血压鼠脑底动脉增加的ET-1能免疫反应阳性纤维可能与脑血管的神经源性调节有关;高密度的ET-1能神经纤维可能涉及高血压时期脑血流的调节。Objective To investigate the relationship between endothelin-1 （ ET-1 ） perivascular nerves and the neurogenic regulation of cerebral vessels in spontaneously hypertensive rats （ SHRs）, and whether ET-1 participates in the regulation of cerebral blood flow during high blood pressure in SHR. Methods Immunohistochemical techniques were used to observe the ET-1 immunoreactive nerves on cerebral arteries, including anterior cerebral artery （ACA）, middle cerebral artery （ MCA）, posterior cerebral artery （PCA） and basilar artery （ BA）, in SHRs and normotensive Wistar rat controls. Results The area density of ET-1 perivascular nerves on cerebral arteries was denser in SHRs than in control. Conclusion The experimental results suggest that enhanced ET-1 perivascu- lar nerves on cerebral artery may play an important role in the neurogenic regulation of cerebral vessels in SHRs. The elevated ET-1 nerve fiber density of cerebral arteries may be involved in the regulation of the cerebral blood flow during pronounced arterial hypertension in SHRs.

关 键 词：脑动脉 内皮素-1 神经分布 高血压 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]