超微粉通心络对麻醉犬急性心肌梗死的作用  

Effects of Tongxinluo Ultramicro-pulverization on acute myocardial infarction in anaesthetic dogs

作　　者：朱慧明 唐思文 张会欣 王宏涛 赵韶华 贾振华 吴以岭 

机构地区：[1]河北以岭医药研究院

出　　处：《中国临床药理学与治疗学》2008年第3期328-331,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家"973"计划资助项目(2005CB523301)

摘　　要：目的:观察超微粉通心络对犬急性心肌梗死的作用。方法:结扎犬冠状动脉前降支中段制备犬急性心肌梗死模型;采用氯化三苯基四氮唑(TTC)染色法和心外膜电图测定心肌梗死面积、缺血程度;测定血氧饱和度和血氧分压,计算氧利用率。结果:超微粉通心络明显减小TTC染色法所显示的心肌梗死范围,显著降低心肌梗死犬氧利用率;心外膜电图数据显示,超微粉通心络组与给药前及与模型组比较都明显降低犬心肌缺血程度,犬心肌缺血范围明显减小。结论:超微粉通心络可恢复心肌梗死犬氧利用率,对犬急性心肌梗死有明显的保护作用。AIM： To study the effects of Tongxinluo Ultramicro-pulverization （TXLU） on acute myocardial infarction in anaesthetic dogs. METHODS： The acute myocardial infarction model was made by ligation of left anterior descending （LAD） artery. The experiments adopted the epicardial electrogram to measure the scope and degree of myocardial isehemia, the quantitative histologic assay （triphenytetrazolium chloride, TIC stain） to determine the size of myocardial infarction. The blood oxygen pressure and oxygen saturation were measured by blood-gas analyzer. The utilization rate of myocardial oxygen was calculated. RESULTS： Compared with the controls and before dosing, the TXLU obviously alleviated the degree of myocardial isehemia （∑-ST） and narrowed the ischemic area indicated by the epicardium electrograph data display and TIC staining. In addition, TXLU could decrease the utilization rate of myocardial oxygen. CONCLUSION： TXLU could attenuate the damage subjected to myocardial ischemia and infarction, restore the utilization ratio of myocardial oxygen.

关 键 词：超微粉通心络 心肌梗死 梗死面积 心外膜电图 

分 类 号：R965.1[医药卫生—药理学]