大肠埃希菌Ⅰ类整合子遗传标记研究  

Study on the genetic marker of class 1 integron in Escherichia.coli

作　　者：李智山[1] 周乐翔[1] 赵建忠[1] 杨燕[1] 邓三季[1] 邹玖明[1] 

机构地区：[1]湖北省襄樊市中心医院检验医学部,湖北襄樊441021

出　　处：《世界感染杂志》2008年第2期113-114,127,共3页World Journal of Infection

摘　　要：目的了解我院大肠埃希菌（ECO）的Ⅰ类整合子遗传标记qacE△1-sull基因存在状况。方法对临床分离的34株ECO菌，采用PCR方法检测Ⅰ类整合子遗传标记qacE△1-sull基因。结果34株ECO菌qacE△1-sull基因阳性有28株（82．4％）。结论本组34株ECO菌药敏实验显示，β-内酰胺酶和氨基糖苷类抗生素耐药性高与Ⅰ类整合子遗传标记qacE△1-sull基因高检出率有关。Objective To investigate the class 1 integron genetic marker （qacE△1-sull gene） of Escherichia.coli in our hospital. Methods Thirty-four strains of Escherichia.coli were isolated from hospitalized patients, and the class 1 integron genetic marker（qacE△1-sull gene） were analyzed by polymerase chain reaction. Results Among Thirty-four strains of Escherichia.coli, The qacE△1-sull gene expression was detected in twenty-eight strains （82.4%）. Conclusions The antimicrobial susceptibility test performed in thirty-four strains of Escherichia.coli indicated that, the high resistance of β-lactam antibiotics and aminoglycoside antibiotics was concerned with the high isolating rate of class l integron genetic marker qacE△1-sull gene.

关 键 词：大肠埃希菌 整合子 基因 

分 类 号：R378.2[医药卫生—病原生物学]