子宫内膜异位症术后复方地索高诺酮用药方法探讨  

Investigation on Different Treatment in Endometriosis with Desogestrel after Surgery

作　　者：张焱[1] 

机构地区：[1]上海市浦东新区妇幼保健院妇产科,上海浦东201206

出　　处：《医学临床研究》2008年第4期601-603,共3页Journal of Clinical Research

摘　　要：【目的】探讨复方地索高诺酮治疗子宫内膜异位症术后患者的临床疗效以及不同药物服用方法对疗效的影响。【方法】子宫内膜异位症进行保守性手术后患者共72例,分为常规周期用药组(35例)与连续用药组(37例),分别采用周期性给药以及连续给药方式进行治疗,用药种类以及剂量一致,两组均于手术后第一次月经来潮5d内开始用药,疗程6个月。比较两种给药方式治疗子宫内膜异位症的疗效、副反应情况以及对内分泌功能的影响。【结果】两组患者的痛经症状缓解明显。两组患者治疗前后促卵泡激素(FSH)、促黄体激素(LH)、雌二醇(E2)、催乳素(PRL)水平均无明显变化,治疗前后比较无统计学差异(P>0.05);两组之间分别比较,也无统计学差异(P>0.05)。【结论】复方地索高诺酮可以有效的治疗子宫内膜异位症;周期性的治疗与连续用药治疗的疗效无明显差异,但当周期性用药治疗无效时,连续用药是一种可供选择的用药方式。[Objective] To explore the clinical effect and the different treatment methods in endometriosis with desogestrel after surgery. [Methods] Seventy two women with endometriosis after conservative surgery were divided into two groups： cyclic pill regimen group （ n = 35） and continuous use group（ n = 37）. All the women were asked to take medicine within the five days of the first menstrual onset after the surgery for 6 months. The clinical efficacy, the adverse reaction and the state of endocrine were compared between the two groups. [Results] The difficult menstruation was released within two groups. No significant difference of the FSH, LH, E2, PRL have been found between pre-surgery and post-surgery in the two groups （ P 〉0.05）, and there was also no difference between the two groups （ P 〉0.05）. [Conclusion] Desogestrel can treat the patients with endometriosis well, and no different clinical effect can be found between the cyclic group and continuous group, but the continuous administration may be a good substitute for the cyclic pill.

关 键 词：避孕药 口服/治疗应用 子宫内膜异位症/外科学 

分 类 号：R711.71[医药卫生—妇产科学]