慢性乙型肝炎、肝硬化患者血清中AFP、CA125、CEA、CA199临床意义的探讨  

Discussion of clinical value of the level of AFP、CA125、CEA、CA199 in the serumof chronic hepatitis B and cirrhosis

作　　者：戚玉海[1] 林向阳[2] 

机构地区：[1]温州医学院检验医学院,2002年级浙江温州32500 [2]温州医学院附属第一医院检验科,浙江温州32500

出　　处：《检验医学教育》2008年第1期47-48,共2页

摘　　要：目的:探讨慢性乙型肝炎、肝硬化患者血清中AFP、CA125、CEA、CA199的变化的临床意义。方法:用化学发光法测定38例慢性乙型肝炎、57例肝硬化(其中无腹水26例,有腹水31例)患者血清中AFP、CA125、CEA、CA199的水平,另设健康对照组54例。结果:慢性肝病患者血清中AFP较正常对照组有轻中度升高,有统计学意义,肝硬化失代偿组升高明显。慢性肝病患者血清中CEA升高仅见于个别病例,慢性肝病患者组与正常对照组比较并无显著性差异。CA125在慢乙肝患者血清中并无明显升高,而在肝硬化特别是失代偿期时升高明显(P<0.01)。CA199在慢性肝病患者血清中有升高,且随病情进展有升高趋势。结论:AFP在慢性肝病患者血清中有升高,可以作为肝脏损害的参考指标。CEA对肝病的评价无特殊意义。CA125在肝硬化失代偿期时明显升高,对判断肝硬化患者有无腹水有一定参考意义。CA199可以用于评价慢性肝病病情的进展。Objective：It is to discussion the change of the level of AFP.CEA.CA125.CA199 in serum of chronic hepatitis B and cirrhosis patients. Methods：The quantity of them are detected with chemiluminescence＇s . It contains 38 cases of chronic hepatitis B. 57 cases of cirrhosis （including 26 cases without ascites and 31 cases with ascites ） and 54 cases of healthy people. Results： The AFP levels in serum of chronic liver diseases patients is statistically higher than that of the healthy control group, especially in that of patients with ascites. The rise of the AFP levels is only found in serum of few patients. There is no big difference between chronic liver diseases patients and normal people. The CA125 levels in serum of cirrhosis patients is higher than that of the healthy control group, especially in that of patients with ascites （P〈0. 01）,but not in the serum of chronic hepatitis B. CA199 levels in serum of chronic hepatitis B and cirrhosis patients are higher than that of healthy control group. Conclusion：The AFP levels in serum of chronic liver diseases patients is higher than that of the healthy control group, and can be used as a consulting factor of the injury of liver. The level of CEA in serum has no consulting value in weighting the worsened of chronic hepatitis B. The mount of CA125 has great relationship with ascites. CA199 may be used as consulting factors in evaluating the worsened of chronic hepatitis B and cirrhosis.

关 键 词：慢性乙型肝炎 肝硬化 AFP CA125 CEA CA199 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]