钙对自发性高血压大鼠肠系膜血管床膜的稳定作用  

The Membrane Stabilization Effect of Calcium on Mesenteric Vascular Beds in Spontaneously Hypertensive Rats

作　　者：王月玲[1] 王磊一[1] 王兴仁 刘志向[1] 柴象枢[1] 

机构地区：[1]山东省医学科学院生理研究室

出　　处：《高血压杂志》1997年第3期175-178,共4页Chinese Journal of Hypertension

摘　　要：目的研究钙对ＳＨＲ肠系膜血管床的膜稳定作用。方法分离麻醉鼠肠系膜血管进行灌流。以灌流压的变化作为其舒缩活动的指标。结果（１）１０ｍｍｏｌ／Ｌ钙可使ＮＥ引起的收缩出现舒张，ＳＨＲ的舒张比ＷＫＹ弱１５．８３％（Ｐ＜０．０５）。（２）在ＫＣｌ收缩的基础上４０ｍｍｏｌ／Ｌ钙也引起血管床的舒张，ＳＨＲ比ＷＫＹ舒张弱１５．０７％（Ｐ＜０．０５）。（３）在无钾及无钙溶液中（不含ＥＧＴＡ）孵育的标本加钙（３．５ｍｍｏｌ／Ｌ）时，ＳＨＲ的反应明显高于ＷＫＹ鼠，但应用ＥＧＴＡ后再重复前次实验，则两者的反应差别消失。结论钙对肠系膜血管床平滑肌有膜稳定作用，ＳＨＲ较ＷＫＹ的此种钙的膜稳定作用减弱。Aim The membrane stabilization effect of calcium on the mesenteric vascular beds in spontaneously hypertensive rats(SHR) was studied. Methods\ The mesenteric artery from anethetized rats were isolated and perfused.\ The prepaartion was suspened in water jacket chamber and perfused at constant flow(4～5 ml/min) with PSS(37℃).\ Perfused pressure maintained at 25 mmHg.\ The vasculature response were determined by perfused pressure. Results \ (1)10 mmol/L Ca 2+ produced relaxation of mesenteric preparation on the background of NE induced contraction.\ The relaxation response of mesenteric artery in SHR was 15 83% that of WKY(P<0 05);(2) 40 mmol/L Ca 2+ produced relaxation of mesenteric preparation on the background of KCl induced contraction.\ The relaxation response in SHR was 15 07% that of WKY as well(P<0 05);(3)After incubation in calcium free and potassium free solution, the response of mesenteric preparation to 3 5 mmol/L Ca 2+ was greater in SHR than that in WKY rats.\ In the presence of EGTA(2 5 mmol/L) the response was not statistically different between SHR and WKY rats.\ Conclusion Calcium exert the membrane stabilization effect which was decreased in SHR.

关 键 词：钙 膜稳定作用 肠系膜血管床 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]