缓释药用材料的发展与缓释型氟尿嘧啶的应用特点  

Development of medical extended release materials and application of extended release

作　　者：陈强[1] 

机构地区：[1]鞍山市中心医院内科,辽宁省鞍山市114001

出　　处：《中国组织工程研究与临床康复》2008年第10期1935-1938,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：深入研究药物新剂型对提高药物疗效、减少不良反应,不仅适应于临床药学研究的迫切需要,而且在医药科研和制药工业的经济效益上均具有重要意义。缓释制剂可按需要在预定期间内向人体提供适宜的血药浓度,减少服用次数并可获得良好的治疗效果。随着给药系统和给药部位的深入,缓释制剂的制备技术和新品种的开发和发展有了更好的前景。一般情况下,缓释制剂主要是通过选择适宜的缓释材料,采用制剂技术来达到延缓释药目的。缓释材料应首先考虑生理因素对缓释剂型性能的影响,如药物的吸收、分布、代谢、药物作用的缓释时间等。各种制备缓释制剂的缓释材料很多,目前可用于生产的缓释材料有40多种。文章重点介绍了缓释药用材料的发展及缓释型氟尿嘧啶的缓释效果。Further researches of medical reagents play an important role on increasing therapeutic effect and reducing adverse effect, which are fitted for the emergent requirements of clinical medicine and the development of medical researches and pharmaceutical industry. Extended release preparation may offer the human body with a suitable blood-drug concentration, reduce the administration and obtain the satisfactory efficiency. The profound administration system and treated site broaden the preparation technique of extended release reagents and the development of new preparations. Generally, extended release reagents are prepared to delay the drug release based on the eligible materials, which should be selected according to the influence of physiologic factors on the performance of extended release reagents, such as drug absorption, distribution, metabolism, and time of extended release, etc. There are various kinds of extended release materials, and over 40 varieties have been applied for the current production. This paper is designed to introduce the development of medical extended release materials and the effect of extended release fluorouracil.

关 键 词：缓释材料 缓释制剂 氟尿嘧啶 靶向性 

分 类 号：R318[医药卫生—生物医学工程]