双相(O／W)识别手性萃取分离萘普生对映体  

Resolution of Naproxen by Two-Phase(O/W) Recognition Chiral Extraction

作　　者：唐课文[1] 陈圆圆[2] 刘佳佳[2] 

机构地区：[1]湖南理工学院化学化工系,湖南岳阳414000 [2]中南大学化学化工学院,长沙410083

出　　处：《中国药学杂志》2008年第8期620-623,共4页Chinese Pharmaceutical Journal

基　　金：国家自然基金项目(20376085);中国博士后科学基金项目(2004035650)

摘　　要：目的研究萘普生在D(L)-酒石酸异丁酯1,2二氯乙烷有机相和羟丙基β-环糊精水相萃取体系中的分配行为;考察酒石酸构型和浓度、羟丙基β-环糊精浓度、水相pH值等因素对萃取性能的影响。方法运用新的手性分离技术-双相(O/W)识别手性萃取。结果羟丙基β-环糊精对S-萘普生对映体的识别能力大于对R-萘普生对映体的识别能力,而L-酒石酸异丁酯的识别能力刚好相反;在羟丙基β-环糊精和L-酒石酸异丁酯萃取体系中,萘普生外消旋体一次萃取分离后R和S对映体的分配系数(kR和kS)分别为8.92和5.41,分离因子(α)达1.65;同时pH值和萃取剂浓度对手性分离能力有显著的影响。结论双相(O/W)识别手性萃取具有较强的手性分离能力,它对外消旋体化合物的制备性分离有着十分重要的意义。OBJECTIVE To investigate the distribution behavior of naproxen enantiomers in the extraction system with D（L）-isobutyl tartrate in 1,2-dichloroethane organic phase and HP-β-CD in aqueous phase, and to evaluate the influence of kind and concentration of tartaric acid esters ,concentration of HP-β-CD and pH on extraction performance were investigated. METHODS A new chiral separation technology two-phase （0/W） recognition chiral extraction was used. RESULTS HP-β-CD owned a higher recognition ability for S-NAP than that for R-NAP, whereas L-isobutyl tartrate owned a higher recognition ability for R-NAP than that for S-NAP. In the extraction system containing HP-β-CD and L-isobutyl tartrate, the distribution ratioes for R-NAP（ kR ） and for S-NAP（ ks） and separation factor（a） were 8. 92, 5.41 and 1.65 after one stage extraction, respectively. Meanwhile, pH and concentration of extractant showed great effects on chiral separation ability. CONCLUSION Two-phase （O/W） recognition chiral extraction is of strong chiral separation ability and great significance for preparative separation of racemic compounds.

关 键 词：双相(O/W)识别 手性萃取 萘普生对映体 

分 类 号：R917[医药卫生—药物分析学]