原发性干燥综合征合并自身免疫性甲状腺疾病临床分析  

Clinical features of autoimmune thyroid disease involvement in primary Sjgren's syndrome

作　　者：于学满[1] 王晓非[1] 

机构地区：[1]中国医科大学附属第一医院风湿免疫科,110001

出　　处：《辽宁医学杂志》2008年第2期69-70,共2页Medical Journal of Liaoning

摘　　要：目的了解原发性干燥综合征(pSS)合并自身免疫性甲状腺疾病(pSS-ATD)的临床特点。方法对279例原发性干燥综合征患者进行回顾性分析,探讨其合并自身免疫性甲状腺疾病的比例及临床特征。结果279例pSS患者中有82例合并有ATD,且患者临床表现多样,其中合并弥漫性毒性甲状腺肿(G raves病)8例占2.87%,合并甲状腺功能减退症56例占20.07%,两者比较差异有显著性意义(P<0.05);合并亚临床甲减18例占6.45%,与甲亢组比较,差异无显著性意义(P>0.05)。结论pSS可以合并多种自身免疫性甲状腺病,其中甲状腺功能减退症和亚临床甲减最常见。Objective To investigate the clinical features of autoimmune thyroid disease（ATD） involvement in primary Sjogren＇ s syndrome （pSS） [ pSS-ATD ]. Methods The clinical data of 279 pSS patients in department of Rheumatology and Immunology, the first affiliated hospital of china medical university were retrospectively reviewed. Results There were a variety of clinical features presentations in pSS, in which 8 patients had Graves disease （GD） and 56 patients had hypothyroidism, accounting for 2. 87% and 20.07% respectively, there are significant difference compared between GD and hypothyroidism （ P 〈0. 05）. Eighteen（6.45% ） of 279 pSS patients were subclinical hypothyroidism, there are no significant difference compared with GD （ P 〉 0. 05 ）. Conclusions A variety of autoimmune thyroid diseases （ATD） may be involved in pSS, in which hypothyroidism and subclinical hypothyroidism frequently occurrs in pSS.

关 键 词：干燥综合征 自身免疫性甲状腺疾病 弥漫性毒性甲状腺肿 甲状腺功能减退症亚临床甲减 

分 类 号：R593.2[医药卫生—内科学] R581[医药卫生—临床医学]