加巴喷丁治疗带状疱疹后神经痛的有效性和安全性研究  

THE EFFICACY AND SAFETY OF GABAPENTIN IN POSTHERPETIC NEURALGIA

作　　者：龚志毅[1] 叶铁虎[1] 郝绒绒[1] 施宇翔[2] 熊利泽[2] 王秋实[3] 王俊科[3] 肖洁[4] 王祥瑞[4] 许华[5] 熊源长[5] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院麻醉科,北京100730 [2]第四军医大学西京医院麻醉科 [3]中国医科大学第一附院麻醉科 [4]上海交通大学仁济医院麻醉科 [5]第二军医大学长征医院麻醉科

出　　处：《中国疼痛医学杂志》2008年第2期72-74,77,共4页Chinese Journal of Pain Medicine

摘　　要：目的:观察加巴喷丁对国人带状疱疹后神经痛的有效性和安全性。方法:带状疱疹后神经痛病人231例随机分为加巴喷丁组和安慰剂组,两组病人分别使用加巴喷丁胶囊1800mg/天或模拟胶囊,总共接受6周的药物治疗。以疼痛缓解程度作为评价的主要疗效指标。其他指标包括疼痛对睡眠影响,疼痛对生活质量影响,病人对治疗效果的评价以及McGill疼痛问卷简表(SF-MPQ)分值的改变。结果:加巴喷丁组和安慰剂组平均每日疼痛分值分别降至4.14±1.89和5.33±1.61,与基础值相比均有显著降低(P值为0.001)。加巴喷丁组较安慰剂组降低更为明显(P值为0.001)。加巴喷丁组病人50%的疼痛缓解程度为27.6%,安慰剂组仅为3.8%(P值为0.001)。加巴喷丁组病人睡眠和生活质量改善的比例分别为35.7%和32.1%,均明显高于安慰剂组的9.5%和6.6%(P值为0.001)。加巴喷丁组头晕及嗜睡的比例明显高于安慰剂组。结论:加巴喷丁可明显降低带状疱疹后神经痛的程度,改善病人的睡眠和生活质量,并有较好的耐受性。Objective： To ohserve the efficacy and safety of gahapentin on postherpetic neuralgia. Methods： Two hundred and thirty-one men and women suffered from postherpetic neuralgia received 1800 mg daily or placebo. The primary outcome was pain relief. Secondary outcomes included sleep interference score, life quality interference score, patient global impression of change and SF-MPQ. Results： At the end of treatment, the average daily pain scores in the gabapentin and placebo groups decreased respectively to 4.14 ± 1.89 and 5.33 ± 1.61 （P =0. 001 ）. More than 50% pain relief of both groups were 27. 6% and 3.8% （P = 0. 001 ） ,respectively. The improvements of sleep interference and life quality interference scores for gabapentin were higher than that of placebo. The most common adverse events of gabapentin were dizziness and somnolence. Conclusion： Gabapentin is effective and safe in the treatment of postherpetic neuralgia.

关 键 词：加巴喷丁 安慰剂 带状疱疹后神经痛 

分 类 号：R752.12[医药卫生—皮肤病学与性病学] R742.1[医药卫生—临床医学]