五味子宁神口服液的急性毒性作用  

Acute toxicologic study on Wuweizi Ningshen oral liquid

作　　者：邓平[1] 杨宏图[2] 常翠[2] 饶曼妮[2] 

机构地区：[1]深圳市第二人民医院药剂科,广东省深圳518035 [2]广东省深圳市人民医院药学部

出　　处：《中国基层医药》2008年第3期416-417,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：基金项目：广东省深圳市科技研发资金基金资助项目（JH200504190090A）

摘　　要：目的观察小鼠口服五味子宁神口服液的急性毒性反应。方法采用最大给药量法测定小鼠口服五味子宁神口服液的急性毒性；以200g生药·kg^-1·d^-1的五味子宁神口服液（相当于临床用量156．3倍）灌胃，连续2周，观察小鼠的生长发育、体质量和主要脏器指数的变化。结果小鼠一般状况、体质量增长、主要脏器系数均无明显差异或异常。结论五味子宁神口服液临床用药范围内应用是比较安全的。Objective To abserve the acute toxicity in mice administered with Wuweizi Ningshen oral liquid. Methods The maximum administration dosage（MAD） of Wuweizi Ningshen oral liquid were determined by admin-istration intragastricly in mice. Wuweizi Ningshen oral liquid was administered for 2 weeks, and the growth condition, body weight growth and index of main viscera were measured. Results The index of growth condition, body weight growth and index of main viscera were in normal ranges. Conclusion It could be concluded that Wuweizi Ningshen oral liquid is safe to be administered in the dose prescribed.

关 键 词：五味子 急性毒性试验 小鼠 

分 类 号：R28[医药卫生—中药学]