6位取代的2-甲基-3-乙氧羰基-4-喹啉酮的微波合成及晶体结构  

Microwave Synthesis and Crystal Structure of 6-Substituted 2-Methyl-3-carbethoxy-4-quinolinones

作　　者：张培[1] 强胜[2] 黄林[1] 黄月芳[1] 杨春龙[1] 

机构地区：[1]南京农业大学理学院,南京210095 [2]南京农业大学生命科学学院,南京210095

出　　处：《化学通报》2008年第4期313-316,共4页Chemistry

基　　金：国家“863计划”项目(2006AA10A214);南京农业大学科技发展基金项目(0506F0005)资助

摘　　要：用微波技术在无溶剂条件下合成了4个6-位取代的2-甲基-3-乙氧羰基-4-喹啉酮类化合物,其结构经红外光谱和元素分析表征,并用X-射线衍射法测定了取代基为甲氧基的标题化合物的晶体结构,其晶体属单斜晶系,P21/n空间群,a=0.67780(14)nm,b=0.68990(14)nm,c=2.7329(6)nm,β=92.34(3)°,V=1.2769(5)nm3,Z=4,Mr=261.27,Dc=1.359g/cm3,μ=0.100mm-1,S=1.097,F(000)=552,最终偏离因子为R1=0.087,wR2=0.200。分子间氢键N—H…O和π-π堆积作用使该化合物分子形成稳定的三维结构。Four 6-Substituted 2-methyl-3-carbethoxy-4-quinolinones were synthesized by microwave technology without supported solvent. They had been eharacteized by IR and elemental analysis. The crystal structure of the titled compound with 6-methoxy was determined by single-crystal X-ray diffraction, the crystal belongs to monoclinic system, space group P2 1/n with a=0.67780（14）nm,b=0.68990（14）nm,c=2.7329（6）nm,β=92.34（3）°,V=1.2769（5）nm^3,Z=4,M,=261.27,Dc=1.359g/cm^3,μ=0.100mm,S=1.097,F（000）=552,the final R1=0.087,ωR2=0.200. It forms a steady three-dimension structure through the intermolecular hydrogen bond N--H…O and the π-π stacking interactions.

关 键 词：2-甲基-3-乙氧羰基-4-喹啉酮微波合成 晶体结构 无溶剂 红外光谱 元素分析表征 

分 类 号：O626[理学—有机化学]