阻塞性睡眠呼吸暂停综合征的白细胞抗原基因测定  

Determination of human leukocyte antigen-DR in patients with obstructive sleep apnea syndrome

作　　者：梁大华[1,2] 刘建红[1] 韦彩周[1] 王武[1] 雷志坚[1] 

机构地区：[1]广西壮族自治区人民医院,广西睡眠呼吸疾病诊疗中心,南宁市530021 [2]广西壮族自治区人民医院呼吸内科

出　　处：《广西医学》2008年第4期472-474,共3页Guangxi Medical Journal

基　　金：广西自然科学基金资助课题(桂科基0236044)

摘　　要：目的观察阻塞性睡眠呼吸暂停综合征(OSAS)患者的白细胞抗原(HLA-DR)基因频率分布情况。方法利用基因芯片技术检测16例OSAS患者(OSAS组)和健康人7例(对照组),确定HLA-DR位点的基因亚型;同时比较两组患者的年龄、睡眠呼吸暂停低通气指数和体重指数。结果OSAS组患者的HLA-DRB3基因频率为41%,明显高于正常对照组(P=0.02),OSAS组患者呼吸暂停低通气指数和体重指数大于对照组(P<0.01,P<0.05)。结论HLA-DRB3基因可能在OSAS发病中起某种作用。Objective To observe the characteristic of the genetic frequency distribution of human leukocyte antigen （ HLA）-DR antigen in patients with obstructive sleep apnea syndrome（OSAS）. Methods Genetic frequencies of HLA-DR were detected by gene chip technology in 16 patients with OSAS and 7 healthy subjects, and the age, apnea-hypopnea index （AHI） and body mass index （BMI） were determinated in them. Results The frequency of HLA-DRB3 in patients with OSAS was found to be significantly higher than that in healthy subjects （P = 0.02 ） ,AHI and mean BMI in patients with OSAS was significantly higher than that in healthy subjects （P 〈 0.01, P 〈 0.05）. Conclusion HLA-DRB3 may play a role in the pathogenesis of OSAS.

关 键 词：睡眠呼吸暂停综合征 白细胞抗原基因 基因芯片技术 

分 类 号：R563.8[医药卫生—呼吸系统]