小木通、绣球藤水提物抗炎、利尿作用比较研究  

Comparative study on the Efficacy and Toxicity between Clematis armandii Franch and C. Montana Buch.-Hum Aqueous Extract

作　　者：张白嘉[1] 曹毓[1] 刘榴[1] 潘嘉[1] 

机构地区：[1]四川省中药研究所,四川成都610041

出　　处：《四川中医》2008年第2期38-39,共2页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省中医药管理局课题(编号:2003A37)

摘　　要：目的:比较研究小木通、绣球藤抗炎、利尿作用及急性毒性。方法:采用蛋清、角叉菜胶所致小鼠足肿胀模型;小鼠利尿试验;急性毒性试验。结果:灌胃给药,小木通对蛋清所致小鼠足肿胀有明显抑制作用,绣球藤对蛋清、角叉菜胶所致小鼠足肿胀有明显抑制作用;绣球藤能明显增加小鼠尿量,明显促进尿中K+、Na+的排出。小木通亦有增加尿量作用趋势,并能明显促进尿中K+排出;小木通、绣球藤小鼠最大耐受量均为300g(原生药)/kg。结论:小木通、绣球藤具有相似的抗炎、利尿作用,绣球藤作用稍优于小木通。小木通、绣球藤急性毒性较小。objective： To compare the anti-inflammatory and diuretic effects of Clematis armandii Franch （ Ⅰ ） and C. Montana Buch. -Hum （ Ⅱ ）, the acute toxicity also be studied. Methods： Anti-inflammatory effect was observed on carrageenan and egg-whlte induced ankle joint swelling mouse model respectively, diuretic effect was observed on mouse model by testing the the urine volume and the contents of K ＋ , Na ＋ in the urine. The acute toxicity was tested by general method. Results： Ⅰ and Ⅱ had significant anti-inflammatory effects. The urine volume and the contents of K ＋ , Na ＋ in the urine were obviously increased by Ⅱ , and only the urine volume and the contents of K ＋ were increased by Ⅰ . The maximum tolerated dose of Ⅰ or Ⅱ was 300g crude drug/kg via i. g. Conclusion： Ⅱ has better anti-inflammatory and diuretic effects than Ⅰ , and Ⅰ and Ⅱ have no significant acute toxicity on mice.

关 键 词：小木通 绣球藤 川木通 抗炎 利尿 

分 类 号：R285.5[医药卫生—中药学]