免疫吸附治疗狼疮性肾炎的远期疗效观察  

Observation on Long-term Effect of Immunoadsorption Therapy on Lupus Nephritis

作　　者：韩志武[1] 姚国乾[1] 徐友平[1] 李靖[1] 沈俊[1] 肖琼[1] 

机构地区：[1]解放军161医院,武汉430010

出　　处：《内科急危重症杂志》2008年第2期69-70,77,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的：观察免疫吸附治疗狼疮性肾炎的远期疗效。方法：82例系统性红斑狼疮患者均合并不同程度的肾脏损害，分为常规治疗组和免疫吸附组。常规治疗组给予泼尼松及环磷酰胺，免疫吸附组在此基础上插入A蛋白免疫吸附治疗1～3次，治疗后随访3年以上，观察患者长期狼疮活动情况及生存率。结果：治疗后患者各项免疫指标、肾脏受损指标显著下降，长期随访结果，大部分患者狼疮活动得到有效控制，部分患者经治疗脱离血液透析。免疫吸附治疗组缓解率及远期生存率均明显优于常规治疗组（P〈0.05）。结论：免疫吸附治疗通过清除患者体内的自身抗体，控制狼疮活动，保护器官功能，可显著改善患者远期生存率，具有其优越性和重要临床价值。Objective：To observe the long-term effect of immunoadsorption therapy on lupus nephritis. Methods：Eighty-two cases of systemic lupus erythematosus with various degree of kidney damage were divided into routine therapy group and immunoadsorption therapy group. Patients with routine treatment group were given predni sone and cyclophosphamide, on the basis of routine treatment, immmunoadsorption group received protein A immunoadsorption treatment for 1 to 3 times. Lupus activity and long-term survival rates were followed up after treatment for more than three years. Results： Various immune parameters, and parameters of kidney damage ameliorated significantly after treatment. In majority of patients lupus activity had been effectively controlled, and some patients withdrew from hemodialysis. The remission rate and long-term survival rate in immunoadsorption group were significantly superior to those of the routine therapy group （P〈0. 05）. Conclusion： Immunoadsorption treatment can sig nificantly improve long-term survival rate and protect organ function in patients with lupus nephritis.

关 键 词：免疫吸附疗法 A蛋白 狼疮性肾炎 

分 类 号：R593.242[医药卫生—内科学]