大黄提取液对大鼠颈总动脉内膜增生防治作用的研究  

Research on the Function of the Extractions of Rhubarb on Preventing and Curing the Intima Hyperplasia of Carotid Artery in Rat

作　　者：冯雪建[1] 卢占军[2] 高登慧[3] 徐在品[3] 邓小燕[4] 崔红玉[1] 

机构地区：[1]河北北方学院动物科技学院,河北张家口075000 [2]扬州大学兽医学院,江苏扬州225009 [3]贵州大学动物科技学院,贵州贵阳550025 [4]重庆大学生物力学与组织工程教育部重点实验室,重庆400044

出　　处：《安徽农业科学》2008年第10期4226-4228,共3页Journal of Anhui Agricultural Sciences

基　　金：国家自然科学基金资助项目(30270360)

摘　　要：[目的]研究大黄提取液对大鼠颈总动脉挤压后内膜增生的防治作用。[方法]正常SD大鼠40只,随机分为动物模型组、阿司匹林组和大黄组(大黄Ⅰ组0.45 g/kg、大黄Ⅱ组1.35 g/kg、大黄Ⅲ组4.05 g/kg)。术后30天取颈总动脉,进行形态学观察。[结果]1.大黄Ⅰ组、阿司匹林组和动物模型组血管壁组织结构基本相似,(内膜+中膜)占有率、管腔横切面积占有率均差异不显著(P>0.05)。2.与动物模型组相比,大黄Ⅱ、Ⅲ组大鼠左侧颈总动脉内膜增生均明显减轻。大黄Ⅲ组(内膜+中膜)占有率差异极显著(P<0.01),大黄Ⅱ、Ⅲ组管腔横切面积占有率均差异极显著(P<0.01)。[结论]大黄提取液对大鼠颈总动脉挤压后内膜增生具有一定的防治作用。The function of Rhubarb on preventing and curing the intima hyperplasia of the squeezed total artery in rat carotid was stud- led. The heahhy SD rats were randomly divided into the animal model, aspirin and Rhubarb group （ Rhubarb Ⅰ ,Ⅱ,Ⅲ groups with 0.45,1.35 and 4.05 g/kg resp. ）. On 30th d after operation, the histomorphology of total arteries of carotid were investigated. The tissue structures of the blood vessel wall were almost like in the aspirin, and Rhubarb Ⅰand animal model groups. And there was no significantly difference between the occupancy the occupancy rote of area of medium and intima and that of lumen crosscut area （ P 〉 0.05）. Gompared with animal model groups, intima hyperplasia of total arteries of carotid in left of rat was decreased obviously in Phubarb Ⅱ and Ⅲ group, the occupancy rate of area of medium and intima in Rhubar Ⅲ group had extremely sinifieantly difference （P 〈0.01） and there was a extremely difference （P 〈0.01） on the occupancy rate of lumen crosscut area between Rhubarb Ⅱ and Ⅲ gin）ups. Tile exlmetions of Rht＆arb could prevent and cue the intima hyperplasia of squeezed carotid artery in rat partly

关 键 词：大黄 大鼠 颈总动脉 内膜增生 

分 类 号：S859.797[农业科学—临床兽医学]