汉族人群胆固醇酯转运蛋白基因和C反应蛋白基因多态性与非瓣膜性房颤的关联  

Association of CETP and CRP gene polymorphisms with non-valvular atrial fibrillation in Chinese Han population

作　　者：杨炜宇[1] 徐力幸[1] 张怀勤[1] 陶志华[2] 段成城[1] 

机构地区：[1]温州医学院附属第一医院心血管内科,325027 [2]温州医学院附属第一医院临床医学检验科,325027

出　　处：《中华医学遗传学杂志》2008年第2期225-229,共5页Chinese Journal of Medical Genetics

摘　　要：目的研究胆固醇酯转运蛋白（cholesteryl ester transfer protein，CETP）基因TaqIB、C反应蛋白（Creactive protein，CRP）基因1444C／T单核苷酸多态性（single nonucleotide polymorphism，SNP）与汉族非瓣膜性房颤的相关。方法选取非瓣膜性房颤患者147例、病例对照147例，应用聚合酶链反应一限制性内切酶片段长度多态性鉴定基因型。结果CETP TaqIB（P=0.005，OR=0.614，B=-0、488）和CRP 1444C／T（P=0.003，0R=2.428，β=0.887）遗传多态性在病例组和对照组间差异有统计学意义。根据性别分组：女性组，吸烟、CETP TaqIS、CRP 1444C／T病例对照间差异有统计学意义；男性组，体重指数和CETP TaqlB病例对照间差异有统计学意义。结论中国汉族CETP TaqlB（B2等位基因为保护性因子）和CRP 1444C／T（T等位基因为危险因子）多态性可能与非瓣膜性房颤相关。吸烟、CRP 1444C／T多态性可能增加女性非瓣膜性房颤遗传易感性；肥胖可能增加男性非瓣膜性房颤遗传易感性。Objective To study whether the polymorphisms of TaqIB of cholesteryl transfer protein （CETP） gene and 1444C/T of C reactive protien （CRP） gene are associated with non-valvular atrial fibrillation in the Chinese Han population. Methods Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） assay was used to detect the distribution of genotypes of CETP TaqIB and CRP 1444C/T in 147 patients with non-valvular atrial fibrillation and 147 control subjects in Chinese Han population. Results （1） The distribution of CETP TaqIB and CRP 1444C/T genotypes was in Hardy-Weinberg equilibrium. （2） A statistically significant difference between patients and controls for CETP TaqIB（P=O.005, OR=0.614, β= -0.488） and CRP 1444C/T （P =0.003, OR= 2.428, = O. 887） was observed. （3） In female group, significant difference was observed in smoking, CETP TaqIB and CRP 1444C/T polymorphisms. And in male group, significant difference was observed in body mass index and CETP TaqIB polymorphisms, Conclusion （1） These results suggest that CETP TaqIB （B2 allele as protective factor） and CRP1444C/T （T allele as risk factor） genetic polymorphisms may be associated with the non-valvular atrial fibrillation in the Chinese Han population. （2） Smoking and CRP1444T single nucleotide polymorphism may induce hereditary susceptibility to non-valvular atrial fibrillation in female. Obesity may induce hereditary susceptibility to non-valvular atrial fibrillation in male.

关 键 词：非瓣膜性房颤 单核苷酸多态性 聚合酶链反应一限制性片段长度多态性 胆固醇酯 转运蛋白基因 C反应蛋白基因 

分 类 号：R686[医药卫生—骨科学]