MAR结合蛋白及其调控功能  

MAR-binding Proteins and their Regulatory Functions

作　　者：王天云[1] 张俊河[1] 张煜[1] 王俐[1] 

机构地区：[1]新乡医学院生物化学与分子生物学教研室,河南新乡453003

出　　处：《中国生物化学与分子生物学报》2008年第4期302-306,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金资助项目(No.30470030)~~

摘　　要：核基质结合区(MAR)是真核生物中能与核基质结合的DNA片段.MAR通过与特异的MAR结合蛋白相互作用,在提高转基因表达水平、降低转基因个体之间表达水平差异以及染色体包装等方面具有重要的调控作用.目前,已在不同物种分离MAR结合蛋白,分别为核基质成分、核仁蛋白、组蛋白、叶绿体蛋白等,它们在调控基因表达、细胞发育、细胞凋亡、染色体包装等方面具有重要的功能.本文综述了目前分离出的MAR结合蛋白及其功能,并对MAR-结合蛋白研究作一展望.Matrix attachment region（MAR）is the DNA sequence that binds to nuclear matrice in eukaryote organisms. MAR plays important role in regulating gene expression by specific interaction with MAR-binding protein to modulate the chromosomal constructions in algae, plants, and animals. So far, several MAR-binding proteins were isolated from human tissues and their functions in chromosome structure maintenance, cell development and apoptosis were characterized. The current understanding of MAR-binding proteins and their biological functions will be summarized in this review.

关 键 词：核基质结合区 核基质 MAR结合蛋白 调控功能 

分 类 号：Q781[生物学—分子生物学]