温血停搏液连续灌注对心肌保护作用的实验研究  

Experimental Studies of Continuous Warm Blood Cardioplegia for Myocardial Protection

作　　者：吴延虎[1] 房士琦[1] 李清泉[1] 黄锦成[1] 

机构地区：[1]南京医科大学第一附属医院胸心外科,210029

出　　处：《心肺血管病杂志》1997年第4期280-282,共3页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：本实验采用离休鼠心模型，比较并评定了冷晶体停搏液和温血停搏液对心肌保护的效果。结果表明：温血停搏液连续灌注有明显加强心肌保护的作用，对高体鼠心准注能减少心肌细胞CK和CK—MB的漏出，加强心肌细胞内ATP含量的储存，增加心肌细胞内线粒体的比表面，降低线粒体的平均分数，其效果明显优于冷晶体停搏液。The potential for myocardial protection with cold crystalloid cardioplegia and warm blood cardiople gia was compared and evaluated with the isolatal rat heart mds. The pram study showed that continous warm blood cardioplegia markedly enhanced myocardial perfection to decrease CK and CK-MB leakage, maintain ATP storage in myocardium, increase mitochondrial speific surface and decrease mitochondrial mean fraction as compared with cold crystalloid Cardioplegia.

关 键 词：心肌保护 冷晶体停搏液 温血停搏液 连续灌注 

分 类 号：R654.2[医药卫生—外科学] R654.1[医药卫生—临床医学]