α1b-干扰素治疗慢性乙型肝炎与慢性丙型肝炎疗效比较  

COMPARION OF EFFICACY OF αlb-IFN IN TREATMENT OF CHRONIC HEPATITIS B AND CHRONIC HEPATITIS C

作　　者：刘月兰[1,2] 王海滨[1,2] 张修礼[1,2] 

机构地区：[1]山东省枣庄市立医院传染科 [2]上海第二军医大学长海医院

出　　处：《泰山医学院学报》1997年第3期200-203,共4页Journal of Taishan Medical College

摘　　要：目的研究国产干扰素（α１ｂ－ＩＦＮ）对慢性乙型肝炎（ＣＢＨ）与慢性丙型肝炎（ＣＨＣ）疗效差异方法对４６例ＣＢＨ与３９例ＣＨＣ患者分别采取用α１ｂ－ＩＦＮ３００万Ｕ隔日一次，疗程３ｍｏ，同时设立对照组ＣＢＨ５７例，ＣＨＣ３３例，于治疗前、治疗后８ｗｋ、治疗结束及治疗后０．５ａ采血清测ＨＢｓＡｇ、ＨＢｅＡｇＨＢＶ、ＤＮＡ、ＨＣＶ、ＲＮＡ并动态观察丙氨酸转氨酶（ＡＬＴ）变化结果对ＣＢＨ及ＣＨＣ的ＡＬＴ复常效果皆优于对照组，并且ＩＦＮ对ＣＨＣ疗效优于ＣＢＨ（Ｐ＜０．０５），ＩＦＮ对ＨＢｓＡｇ、ＨＢｅＡｇ阴转疗效皆不明显（Ｐ＜０．０５），但对ＨＢＶ．ＤＮＡ阴转疗效明显（Ｐ＜０．０５），对ＨＣＶ．ＲＮＡ阴转有明显疗效（Ｐ＜０．０１），并且ＩＦＮ对ＨＣＶ．ＲＮＡ阴转疗效明显优于ＨＢＶ．ＤＮＡ（Ｐ＜０．０５）结论提示ＩＦＮ对ＣＨＣ疗效优于ＣＢＨ。Objective To study the differences of the efficacy of α1b-IFN in treating Chronic Hepatitis B(CBH) and Chronic Hepatitis C(CHC) Methods 46 patiants with CBH and 39 patiants with CHC have been treated for three months by using alb-IFN(3×10 6/qod). Simultaneously, 57 patiants with CBH and 33 patiants with CHC, as the control group, have been observed. The sera of the cases were collected at four periods of the medical experiment, pro-treatment, eight weeks, three months and six months after treatment. HBsAg, HEeAg, HBV. DNA, and HCV. RNA, as a marker of viral reproduction, was then detected and the trend of ALT was also observed. 3. Result The differences of the trend of ALT between the treatment group and the control group in CBH and CHC were significant (P<0.05). And the effect of treatment group on CHC was better than that on CBH (P<0.05). The negative reversion of HBsAg and HBeAg was slight (P>0.05), but the negative reversion of HBV. DNA was obvious (P<0.05) and that of HCV. RNA was much more obvious(P<0.01). The negative reversion of HCV. RNA, in the treatment group was more obvious than that of the HBV.DNA. Conclusion The stuty reveal that the treatment effects with alb-IFN on CHC might be better than that on CHB.

关 键 词：乙型肝炎 丙型肝炎 ALT 干扰素 治疗 

分 类 号：R512.605[医药卫生—内科学]