药物依赖与神经递质相关性研究进展  

Research Process of Relativity between Drug-dependence and Neurotransmitter

作　　者：杨铮[1] 覃斐章[1] 黄仁彬[1] 

机构地区：[1]广西医科大学药理学教研室,南宁530021

出　　处：《中国现代应用药学》2008年第2期102-105,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：中越政府间科技合作联委会第五次会议长期合作研究开发项目(编号:5-303J)

摘　　要：目的综述近5年来部分关于药物依赖与神经递质相关性的研究进展。方法对近几年国内外文献资料进行总结和归纳。结果阿片类药物产生依赖的机制与神经组织对药物产生适应性有关,目前较多研究集中在与药物依赖的强化效应和奖赏效应相关的递质方面,如单胺类递质、神经肽类递质、一氧化氮等。结论药物依赖与体内神经递质变化关系非常密切。OBJECTIVE To introduce the research process between drug-dependence and neurotransmitter during the near five years. METHODS The literatures and data published in the recent years were summarized and analyzed. RESULTS The mechanism of opioid - dependence is relative to the adaptability between nerve tissues and drugs. Most attentions were paid to transmitters which relate to the enhancement and rewarding effect of drug - dependence, such as monamines, neuropeptide, nitrogen monoxidum, etc. CONCLUSION It is extremely relative between drug-dependence and neurotransmitter.

关 键 词：药物依赖 神经递质 单胺类 神经肽 

分 类 号：R996.5[医药卫生—毒理学]