抗感染药物致剥脱性皮炎102例  

Retrospective analysis of 102 cases of exfoliative dermatitis induced by anti-infective drugs

作　　者：丁洁卫 唐志华 张林 陈洁[2] 

机构地区：[1]浙江省绍必市人民医院药剂科,浙江绍兴312000 [2]浙江省金华职业技术学院医学院中药041班,浙江金华321007

出　　处：《中国现代应用药学》2008年第2期164-167,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的通过对抗感染药物致剥脱性皮炎不良反应的病例分析，为临床安全用药提供依据。方法对1994～2006年国内公开报道的102例抗感染药物致剥脱性皮炎文献病例进行统计分析。结果抗感染药物致剥脱性皮炎男女发生比率为2.09：1，其中男的占67．6％，女的占32．4％；主要以口服和静脉滴注为主；所涉及的抗感染药物有13类37种，以抗结核药为最多；死亡病例有11例，占10.8％。结论临床上应加强对重点药物的监测，避免和减少抗感染药物致剥脱性皮炎的发生。OBJECTIVE To provide reliable data for safe use of drugs by evaluating the cases of exfoliative dermatitis induced by anti-infective drugs. METHODS 102 cases of exfoliative dermatitis induced by anti-infective drugs from 1994 to 2006 were analyzed statistically. RESULTS Among the total 102 cases, the ratio of male and female was 2. 09： 1. The percentage was 67. 6% and 32.4%, respectively; Oral and intravenous administration were the main routes; All the referred drugs consisted of 13 categories, involving 37 kinds of drugs; The anti-tuberculosis drug was on the top of the all. 11 death cases accounted for 10. 8%. CONCLUSION Related drugs should be monitored in clinical practice to avoid and decrease the exfoliative dermatitis induced by anti-infective drugs.

关 键 词：抗感染药物 剥脱性皮炎 药物不良反应 

分 类 号：R978.1[医药卫生—药品]