甲苯咪唑药物不良反应文献分析  

Analysis of Adverse Reactions Induced by Mebendazole

作　　者：殷为勇[1] 郑荣远[1] 杨学志[1] 朱振国[1] 童巧文[1] 

机构地区：[1]温州医学院附属第一医院神经内科,浙江温州325000

出　　处：《药物流行病学杂志》2008年第2期84-87,共4页Chinese Journal of Pharmacoepidemiology

基　　金：国家食品药品监督管理局药品评价中心资助项目

摘　　要：目的:综述甲苯咪唑引起的各种不良反应的文献报道,为甲苯咪唑的临床再评价提供科学依据。方法:检索1994～2004年国内外医药文献中甲苯咪唑引发的不良反应资料。应用流行病学和文献计量学方法对病例资料进行整理与归纳。结果:甲笨咪唑ADR分布广泛,涉及多个系统器官,儿童、中老年是主要受害者,潜伏期长短取决于ADR的种类,ADR类型多样化。结论:甲苯咪唑存在一定的药物安全性隐患。因此需加强甲苯咪唑的规范化用药及上市后再评价。Objective ： To review literature reports of varieties of ADRs induced by mebendazole to provide a scientific foundation for clinical revaluation of mebendazole. Method： The related literatures in the internal and external medicine medical database in 1994 -2004 were explored, and then both analysis and statistics were conducted with the methods of epidemiology and literature analysis. Result： ADRs induced by mebendazole could be involved in multiple organs. Most victims were children and the elderly. Their latent periods were determined by the types of ADRs, which had a variety of forms. Conclusion： Mebendazole was potentially unsafe. So we should strengthen our rational drug use and post-marketing revaluation of safety,

关 键 词：甲苯咪唑 药物不良反应 驱虫药 文献分析 

分 类 号：R978.63[医药卫生—药品]