婴幼儿喘息性疾病血清总IgE水平及其与哮喘的相关性  

Correlation Between the Total Serum IgE Level of Asthmatic Diseases in Infants and the Development of Asthma

作　　者：陈和斌[1] 贾德胜[1] 王石[1] 胡红兵[2] 

机构地区：[1]武汉市儿童医院呼吸科,武汉430016 [2]武汉市儿童医院检验科

出　　处：《药物流行病学杂志》2008年第2期127-128,共2页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:探讨婴幼儿喘息性疾病急性发作期血清总IgE水平。方法:测定964例临床诊断为毛细支气管炎和喘息性支气管炎而住院的2岁以下婴幼儿血清总IgE。结果:78.9%的患儿血清总IgE高于正常参考值,其中男占74.1%,女占25.9%,毛细支气管炎血清总IgE增高者为243例,占该病总数的60.3%,喘息性支气管炎血清总IgE增高者为518例,占该病总数的92.3%。328例全程跟踪随访中有76例先后被确诊为儿童支气管哮喘,比例为23.2%。结论:78.9%的婴幼儿喘息急性发作期其血清总IgE均升高,推断IgE在婴幼儿喘息的发生和发展中有着重要的作用,也是临床评价是否演变成为儿童支气管哮喘一个重要的参数依据。Objective： To study the total serum IgE level of infant＇s asthmatic diseases in acute attacks and its effect on the development of wheezing. Method： The serum IgE levels of 964 children （younger than two years old） diagnosed as asthmatic bronchitis or bronchiolitis were measured by immune dispersion nephelometer. Result： 78.9% childrens had high E levels （ females took up 25, 9% and males, 74.1% ） , asthmatic bronchitis accounted for 92.3% of the total and bronchiolitis, 60.3%, Of the 328 infants involved in our research, 76 were diagnosed as asthma at last, which accounted for 23.2%, Conclusion： 78.9% infants had a high level of IgE in an acute phase. There was a prominent relativity between IgE and the development of asthma. The increased IgE level of asthmatic bronchitis was obviously higher than that of the bronchiolitis. There appeared to be a connection between the IgE level and the occurrence of asthmatic bronchitis together with the development of asthma.

关 键 词：婴幼儿 血清总IGE 毛细支气管炎 喘息性支气管炎 

分 类 号：R725.6[医药卫生—儿科]