强化胰岛素血糖控制治疗对危重症患者预后的影响  

Intensive insulin therapy： its effect on the prognosis of critically ill patients

作　　者：南佳彦[1] 朱本章[2] 高烨[1] 韩燕[3] 张启云[1] 

机构地区：[1]西安交通大学医学院第一附属医院急诊科,710061 [2]西安交通大学医学院第一附属医院内分泌科,710061 [3]西安交通大学医学院医学分子中心

出　　处：《中华内分泌代谢杂志》2008年第2期141-142,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：将62例危重患者随机分为两组，在基础治疗相同的情况下分别给予强化胰岛素血糖控制治疗和常规治疗。观察临床疗效并测定外周血单个核细胞NF-κB活性和血浆细胞间黏附分子1（ICAM-1）水平。结果提示强化胰岛素治疗可改善危重症患者预后，胰岛素有可靠的抗炎作用。A total of 62 critically ill patients were randomly allocated to the intensive insulin therapy group and the conventional insulin therapy group. The effect of therapy on the prognosis, the activity of NF-κB in peripheral blood monouclear cells and plasma intercellular adhesion molecule-1 level were investigated. The results showed that the intensive insulin therapy may improve the prognosis and insulin had a reliable anti-inflammatory effect in the critically ill patients.

关 键 词：胰岛素 抗炎作用 NF-ΚB 细胞间黏附分子1 

分 类 号：R587.1[医药卫生—内分泌] R459.7[医药卫生—内科学]