血糖波动诱导大鼠骨髓出现胰岛样细胞  

Glycemic excursion-induced islet-like cells in rat bone marrow

作　　者：武晓泓[1] 朱剑[1] 蒋晶晶[1] 徐瑜[1] 刘翠萍[1] 茅晓东[1] 徐宽枫[1] 刘超[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,210029

出　　处：《中华内分泌代谢杂志》2008年第2期208-209,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：江苏省自然科学基金（BK2007251）

摘　　要：本研究采用腹腔注射葡萄糖诱导SD大鼠血糖波动模型，发现骨髓中出现胰岛素、C肽、胰高血糖素、生长抑素和胰淀粉样多肽阳性细胞团簇，并表达胰岛发育和功能相关基因。Glycemic excursion was induced in SD rats by intraperitoneal injection of 50% glucose solution, and cells isolated from bone marrow of these rats showed cell clusters which expressed insulin, c-peptide, glucagon, somatostatin and islet amyloid polypeptide, and other genes related to islet-cells development and functions.

关 键 词：血糖波动 骨髓 胰岛样细胞 大鼠 SPRAGUE-DAWLEY 

分 类 号：R587.1[医药卫生—内分泌]