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作 者:李莎莎[1] 陶冶[2] 罗志娟[1] 刘其锋[2] 章崇杰[1] 胡丽娟[1]
机构地区:[1]四川大学华西基础与法医学院免疫教研室,成都610041 [2]四川大学华西医院肾脏内科,成都610041
出 处:《四川大学学报(自然科学版)》2008年第2期426-430,共5页Journal of Sichuan University(Natural Science Edition)
基 金:2006年度校青年基金(0040105505038)
摘 要:研究曲尼司特对环孢素A(CsA)慢性肾毒性大鼠的肾脏保护作用,发现曲尼司特能减低环孢素A慢性肾毒性大鼠血浆和肾组织中AngⅡ的含量,并下调肾组织中ET-1的表达.结果表明曲尼司特可能通过下调环孢素A慢性肾毒性大鼠血浆和肾组织中AngⅡ的的水平以及肾组织中ET-1的表达,减轻肾脏病理损害,发挥其肾脏保护作用.To investigate the effects of tranilast, the anti-allergic agent N-(3,4-dimethoxyciannamoyl)-anthranilic acid, on angiotensin Ⅱ and endothelin-1 in rats with chronic cyclosporin A nephrotoxicity. It was showed: The expression of Ang Ⅱ in the plasma and cortex of kidneys in group M showed significantly higher than it in group N (489.22± 9.79 versus 420.21 ± 9.36× 10^- 12 g/mL; 82.72 ± 8.69 versus 40.74 ± 5.32 × 10^-12 g/mg tissue). Like irbesartan(457.69 ± 5. 13 × 10^-12 g/mL; 53.93 ± 5.44 × 10^-12 g/mg tissue), Tranilast significantly decreased the level of Ang Ⅱ in plasma (466.25 ±16.87 × 10^-12 g/mL) and kidney tissues(62.25 ± 14.31 × 10^-12 g/mg tissue). Morphologically, kidneys in group M exhibited significantly more fibrosis, which was blunted by tranilast. In addition, tranilast decreased the expression of ET-1 in kidneys of rats with chronic cyclosporin A nephrotoxicity. Tranilast showed a renal protective effect on chronic cyclosporine A nephrotoxicity of rat model by decreasing the level of endothelin-1 and angiotensin Ⅱ.
关 键 词:曲尼司特 环孢素A慢性肾毒性 血管紧张素Ⅱ 内皮素-1
分 类 号:R318.06[医药卫生—生物医学工程]
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