中药祛屑洗药抗马拉色菌体外药敏实验研究  

Experimental study on the susceptibility of Malassezia furfur to Quxie Lotion in vitro

作　　者：邱莹[1] 于腾[2] 高敏[1] 曹淑芳 杜锡贤[1] 

机构地区：[1]济宁市第一人民医院皮肤科,272011 [2]济宁医学院临床学院 [3]汶上县中医院

出　　处：《中国麻风皮肤病杂志》2008年第4期271-272,共2页China Journal of Leprosy and Skin Diseases

摘　　要：目的：观察桑白皮、鱼腥草、川椒、皂角、硼砂、红花及其混合液体外抑制马拉色菌的效果。方法：参照美国国家临床实验标准化委员会（NCCLS）制定的M27-A方案中酵母菌微量稀释法,采用含橄榄油的液体培养基测定敏感性。结果：中药复方制剂的MIC值最低,为312.5mg/L,单味药中鱼腥草MIC值低于其它各药,在312.5-125mg/L之间,并且对糠秕马拉色菌和球形马拉色菌较敏感。结论：复方制剂抗马拉色菌的作用最好,说明复方中各单味药间有相互协同作用。单味药以鱼腥草最为敏感,并有菌种的差异。Objective： To test the effect of mulberry root bark, cordate houttuynia, Sichuan pepper, gleditsia fruit, borax, safflower and its intermixture on the inhibition of the growth of Malasseziafurfur. Method： Referring to M27 - A plan of National Committee for Clinical Laboratory Standards （NCCLS） ： formulates yeast microdilution, the sensitivity was tested by olive oil the liquid media. Results： MIC value of Quxie Lotion was lowest （312.5mg/L）, compared with single herbs in the compound. The MIC value of cordate houttuynia in the compound was lower （312.5 - 125 mg/L） than other herbs. The fungi bran M. furfur and sphere M. furfur were more sensitive to cordate houttuynia. Conclusion： Compound prescription is better than other single ingredients against M. furfur, indicaring that the single ingredient in the compound has a synergic function against the fungi. Although the fungi are most sensitive to cordate houttuynia among the ingredients of the compound, the effect is species dependent.

关 键 词：祛屑洗药 马拉色菌 抗真菌 最小抑菌浓度 

分 类 号：R285[医药卫生—中药学]