支气管哮喘患者诱导痰中尾加压素Ⅱ的变化及其意义  

Changes of urotensin II level in induced sputum of patients with asthma

作　　者：伍蕊[1] 陈亚红[1] 姚婉贞[1] 王配配[1] 耿彬[2] 唐朝枢[2] 

机构地区：[1]北京大学第三医院呼吸内科,北京100083 [2]北京大学医学部生理系

出　　处：《中国呼吸与危重监护杂志》2008年第2期128-131,共4页Chinese Journal of Respiratory and Critical Care Medicine

基　　金：国家自然科学基金资助项目(编号:30300143和30440073)

摘　　要：目的探讨尾加压素Ⅱ(UⅡ)在哮喘发病中的意义。方法采用放射免疫法测定哮喘患者在急性发作期和治疗后缓解期诱导痰中UⅡ含量,并常规进行肺功能检测和诱导痰细胞计数分类。结果26例哮喘患者在急性发作期和临床缓解期诱导痰UⅡ含量分别为(58.88±47.38)pg/mL及(12.69±12.78)pg/mL,二者差异显著(t=4.779,P<0.01);急性发作期诱导痰UⅡ含量随病情恶化而升高,但差异无统计学意义(P>0.05);男性与女性之间、吸烟与不吸烟之间诱导痰UⅡ含量差异无统计学意义(P>0.05);哮喘急性发作期诱导痰UⅡ含量与第1秒用力呼气容积(FEV1)占预计值百分比呈负相关(r=-0.326,P<0.05),与诱导痰细胞总数和中性粒细胞百分比无明显相关性(P>0.05)。结论哮喘时气道UⅡ分泌增加,UⅡ可能参与哮喘的发病。Objective To investigate the role of urotensin Ⅱ（U-Ⅱ） in the pathogenesis of asthma. Methods Lung function, differential cell count and level of U-Ⅱ in induced sputum were studied in 26 asthmatic patients in acute exacerbation and in clinical remission. Results Induced sputum U-Ⅱ level from acute asthma was higher than that of remissed asthma [（58.88±47.38）pg/mL vs （ 12.69±12. 78）pg/mL,P 〈 0.01]. Induced sputum U-Ⅱ levels of asthma patients in acute exacerbation had a tendency to increase as disease deteriorated, which negatively correlated with FEV1% predicted （r=-0.326,P 〈0.05） , but did not with sputum total cell and neutrophil counts （ P 〉 0.05 ）. No significant difference of induced sputum U-Ⅱ levels was found between male and female, smokers and non-smokers. Conclusion U-Ⅱ may play a role in acute exacerbation of asthma.

关 键 词：哮喘 尾加压素 诱导痰 

分 类 号：R562.25[医药卫生—呼吸系统] R544.1[医药卫生—内科学]